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Mouse Anti-ADI1 Recombinant Antibody (V2-634144) (CBMAB-AP163LY)


See all ADI1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-634144
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Raised against amino acids 34-171 mapping within an internal region of ARD of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate).
IF(ICC)1:50-1:500
ELISA1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin.
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Acireductone Dioxygenase 1
Introduction
This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Entrez Gene ID
55256
UniProt ID
Q9BV57
Alternative Names
Acireductone Dioxygenase 1; Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail Binding Protein-1; Acireductone Dioxygenase (Fe(2+)-Requiring); Submergence-Induced Protein-Like Factor; Fe-ARD; MTCBP1; ARD; Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1; 1,2-Dihydroxy-3-Keto-5-Methylthiopentene Dioxygenase; Acireductone Dioxygenase (Ni(2+)-Requiring); MT1-MMP Cytoplasmic Tail-Binding Protein-1;
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.
Biological Process
L-methionine salvage from methylthioadenosine
Methionine metabolic process
Cellular Location
Nucleus; Cell membrane; Cytoplasm. Localizes to the plasma membrane when complexed to MMP14.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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