ADI1

This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Full Name
ADI1
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.
Biological Process
L-methionine salvage from methylthioadenosine
Methionine metabolic process
Cellular Location
Nucleus; Cell membrane; Cytoplasm. Localizes to the plasma membrane when complexed to MMP14.
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Anti-ADI1 antibodies

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Mouse Anti-ADI1 Recombinant Antibody (V2-634144) (CBMAB-AP163LY)

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Target: ADI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-634144
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-ADI1 Recombinant Antibody (V2-179920) (CBMAB-A1304-YC)

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Target: ADI1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-179920
Application*: WB, E
Datasheet SDS

Mouse Anti-ADI1 Recombinant Antibody (V2-179919) (CBMAB-A1303-YC)

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Target: ADI1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-179919
Application*: E, WB
Datasheet SDS

Mouse Anti-ADI1 Recombinant Antibody (V2-179918) (CBMAB-A1302-YC)

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Target: ADI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179918
Application*: F, IH, WB
Datasheet SDS

Mouse Anti-ADI1 Recombinant Antibody (V2-179917) (CBMAB-A1301-YC)

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Target: ADI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179917
Application*: F, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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