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Mouse Anti-ADIPOR1 Recombinant Antibody (V2-179980) (CBMAB-A1366-YC)

Provided herein is a Mouse monoclonal antibody against Human Adiponectin Receptor 1. The antibody can be used for immunoassay techniques, such as WB.
See all ADIPOR1 antibodies
Published Data
Mouse Anti-ADIPOR1 Recombinant Antibody (CBYC-A367) (CBMAB-A1366-YC) in WB
The thermal stability of WT AdipoR1 and Mut AdipoR1 plasmid after treatment with Schisandrin A using CETSA. ...View More
Wang, X., Li, Q., Sui, B., Xu, M., Pu, Z., & Qiu, T. (2022). Schisandrin a from Schisandra chinensis attenuates Ferroptosis and NLRP3 Inflammasome-mediated Pyroptosis in diabetic nephropathy through mitochondrial damage by AdipoR1 Ubiquitination. Oxidative Medicine and Cellular Longevity, 2022.
Mouse Anti-ADIPOR1 Recombinant Antibody (CBYC-A367) (CBMAB-A1366-YC) in WB
ADP and ADP1R proteins in abdominal fat. Data are presented as the mean ± SD (n = 6). ...View More
Wang, H., Liu, S., Li, J., Wang, L., Wang, X., Zhao, J., ... & Lin, H. (2020). 5-Hydroxytryptophan Suppresses the Abdominal Fat Deposit and Is Beneficial to the Intestinal Immune Function in Broilers. Frontiers in Physiology, 11, 655.
Mouse Anti-ADIPOR1 Recombinant Antibody (CBYC-A367) (CBMAB-A1366-YC) in WB
AdipoR1 protein levels were analyzed by western blotting in different peripheral tissues (Heart (H), Liver (Liv), Adipose Tissue (AT, pectoral (pM) and leg muscles (LgM) from six animals. Vinculin was used as a loading control. Data are represented as mean ± SEM (n = 6 animals). Different letters indicate a significant difference. ...View More
Expression of adiponectin, chemerin and visfatin in plasma and different tissues during a laying season in turkeys

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179980
Antibody Isotype
IgM
Application
WB

Basic Information

Immunogen
Synthetic peptide corresponding to Human ADIPOR1 aa 350 to the C-terminus (C terminal) conjugated to keyhole limpet haemocyanin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB10 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Buffer
1% BSA
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
adiponectin receptor 1
Introduction
ADIPOR1 is a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signal
Entrez Gene ID
51094
UniProt ID
Q96A54
Alternative Names
Adiponectin Receptor 1; Progestin And AdipoQ Receptor Family Member 1; Progestin And AdipoQ Receptor Family Member I; TESBP1A; PAQR1; Adiponectin Receptor Protein 1; ACDCR1; CGI-45; CGI45;
Function
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).
Biological Process
Adiponectin-activated signaling pathway
Fatty acid oxidation
Glucose homeostasis
Hormone-mediated signaling pathway
Leptin-mediated signaling pathway
Negative regulation of cell growth
Negative regulation of epithelial cell migration
Negative regulation of epithelial to mesenchymal transition
Negative regulation of NIK/NF-kappaB signaling
Negative regulation of receptor signaling pathway via JAK-STAT
Positive regulation of cold-induced thermogenesis
Positive regulation of insulin receptor signaling pathway
Positive regulation of receptor signaling pathway via JAK-STAT
Regulation of fatty acid biosynthetic process
Regulation of glucose metabolic process
Regulation of lipid metabolic process
Cellular Location
Cell membrane. Localized to the cell membrane and intracellular organelles.
Topology
Cytoplasmic: 1-136 aa
Helical: 137-157 aa
Extracellular: 158-170 aa
Helical: 171-191 aa
Cytoplasmic: 192-203 aa
Helical: 204-224 aa
Extracellular: 225-234 aa
Helical: 235-255 aa
Cytoplasmic: 256-264 aa
Helical: 265-285 aa
Extracellular: 286-298 aa
Helical: 299-319 aa
Cytoplasmic: 320-337 aa
Helical: 338-358 aa
Extracellular: 359-375 aa

Chen, Y. J., Lin, C. W., Peng, Y. J., Huang, C. W., Chien, Y. S., Huang, T. H., ... & Ding, S. T. (2021). Overexpression of Adiponectin Receptor 1 Inhibits Brown and Beige Adipose Tissue Activity in Mice. International journal of molecular sciences, 22(2), 906.

Cicekdal, M. B., Kazan, B. T., Tuna, B. G., Ozorhan, U., Ekici, I. D., Zhu, F., ... & Yilmaz, B. (2021). Effects of two types of energy restriction on methylation levels of adiponectin receptor 1 and leptin receptor overlapping transcript in a mouse mammary tumour virus-transforming growth factor-α breast cancer mouse model. British Journal of Nutrition, 125(1), 1-9.

Ramos-Ramírez, P., Malmhäll, C., Johansson, K., Adner, M., Lötvall, J., & Bossios, A. (2020). Lung Regulatory T Cells Express Adiponectin Receptor 1: Modulation by Obesity and Airway Allergic Inflammation. International Journal of Molecular Sciences, 21(23), 8990.

Tanabe, H., Fujii, Y., Okada-Iwabu, M., Iwabu, M., Kano, K., Kawana, H., ... & Yokoyama, S. (2020). Human adiponectin receptor AdipoR1 assumes closed and open structures. Communications biology, 3(1), 1-11.

Pal, S., Porwal, K., Rajak, S., Sinha, R. A., & Chattopadhyay, N. (2020). Selective dietary polyphenols induce differentiation of human osteoblasts by adiponectin receptor 1-mediated reprogramming of mitochondrial energy metabolism. Biomedicine & Pharmacotherapy, 127, 110207.

Pepin, M. E., Koentges, C., Pfeil, K., Gollmer, J., Kersting, S., Wiese, S., ... & Bugger, H. (2019). Dysregulation of the mitochondrial proteome occurs in mice lacking adiponectin receptor 1. Frontiers in endocrinology, 10, 872.

Zhao, L., Chen, S., Sherchan, P., Ding, Y., Zhao, W., Guo, Z., ... & Zhang, J. H. (2018). Recombinant CTRP9 administration attenuates neuroinflammation via activating adiponectin receptor 1 after intracerebral hemorrhage in mice. Journal of neuroinflammation, 15(1), 1-14.

Kim, S., Lee, Y., Kim, J. W., Son, Y. J., Ma, M. J., Um, J. H., ... & Kim, B. B. (2018). Discovery of a novel potent peptide agonist to adiponectin receptor 1. PLoS One, 13(6), e0199256.

Peng, Y. J., Shen, T. L., Chen, Y. S., Mersmann, H. J., Liu, B. H., & Ding, S. T. (2018). Adiponectin and adiponectin receptor 1 overexpression enhance inflammatory bowel disease. Journal of biomedical science, 25(1), 1-13.

Kim, M. W., Bin Abid, N., Jo, M. H., Jo, M. G., Yoon, G. H., & Kim, M. O. (2017). Suppression of adiponectin receptor 1 promotes memory dysfunction and Alzheimer’s disease-like pathologies. Scientific reports, 7(1), 1-10.

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For research use only. Not intended for any clinical use.

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