Human ADIPOR1 ELISA Kit (V2LY-0626-LY3580)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.31 ng/mL
Detection Range
0.5-150 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
42.6 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
adiponectin receptor 1
Function
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).
Biological Process
Adiponectin-activated signaling pathway
Fatty acid oxidation
Glucose homeostasis
Hormone-mediated signaling pathway
Leptin-mediated signaling pathway
Negative regulation of cell growth
Negative regulation of epithelial cell migration
Negative regulation of epithelial to mesenchymal transition
Negative regulation of NIK/NF-kappaB signaling
Negative regulation of receptor signaling pathway via JAK-STAT
Positive regulation of cold-induced thermogenesis
Positive regulation of insulin receptor signaling pathway
Positive regulation of receptor signaling pathway via JAK-STAT
Regulation of fatty acid biosynthetic process
Regulation of glucose metabolic process
Regulation of lipid metabolic process
Cellular Location
Cell membrane. Localized to the cell membrane and intracellular organelles.
Topology
Cytoplasmic: 1-136 aa
Helical: 137-157 aa
Extracellular: 158-170 aa
Helical: 171-191 aa
Cytoplasmic: 192-203 aa
Helical: 204-224 aa
Extracellular: 225-234 aa
Helical: 235-255 aa
Cytoplasmic: 256-264 aa
Helical: 265-285 aa
Extracellular: 286-298 aa
Helical: 299-319 aa
Cytoplasmic: 320-337 aa
Helical: 338-358 aa
Extracellular: 359-375 aa

Chen, Y. J., Lin, C. W., Peng, Y. J., Huang, C. W., Chien, Y. S., Huang, T. H., ... & Ding, S. T. (2021). Overexpression of Adiponectin Receptor 1 Inhibits Brown and Beige Adipose Tissue Activity in Mice. International journal of molecular sciences, 22(2), 906.

Cicekdal, M. B., Kazan, B. T., Tuna, B. G., Ozorhan, U., Ekici, I. D., Zhu, F., ... & Yilmaz, B. (2021). Effects of two types of energy restriction on methylation levels of adiponectin receptor 1 and leptin receptor overlapping transcript in a mouse mammary tumour virus-transforming growth factor-α breast cancer mouse model. British Journal of Nutrition, 125(1), 1-9.

Ramos-Ramírez, P., Malmhäll, C., Johansson, K., Adner, M., Lötvall, J., & Bossios, A. (2020). Lung Regulatory T Cells Express Adiponectin Receptor 1: Modulation by Obesity and Airway Allergic Inflammation. International Journal of Molecular Sciences, 21(23), 8990.

Tanabe, H., Fujii, Y., Okada-Iwabu, M., Iwabu, M., Kano, K., Kawana, H., ... & Yokoyama, S. (2020). Human adiponectin receptor AdipoR1 assumes closed and open structures. Communications biology, 3(1), 1-11.

Pal, S., Porwal, K., Rajak, S., Sinha, R. A., & Chattopadhyay, N. (2020). Selective dietary polyphenols induce differentiation of human osteoblasts by adiponectin receptor 1-mediated reprogramming of mitochondrial energy metabolism. Biomedicine & Pharmacotherapy, 127, 110207.

Pepin, M. E., Koentges, C., Pfeil, K., Gollmer, J., Kersting, S., Wiese, S., ... & Bugger, H. (2019). Dysregulation of the mitochondrial proteome occurs in mice lacking adiponectin receptor 1. Frontiers in endocrinology, 10, 872.

Zhao, L., Chen, S., Sherchan, P., Ding, Y., Zhao, W., Guo, Z., ... & Zhang, J. H. (2018). Recombinant CTRP9 administration attenuates neuroinflammation via activating adiponectin receptor 1 after intracerebral hemorrhage in mice. Journal of neuroinflammation, 15(1), 1-14.

Kim, S., Lee, Y., Kim, J. W., Son, Y. J., Ma, M. J., Um, J. H., ... & Kim, B. B. (2018). Discovery of a novel potent peptide agonist to adiponectin receptor 1. PLoS One, 13(6), e0199256.

Peng, Y. J., Shen, T. L., Chen, Y. S., Mersmann, H. J., Liu, B. H., & Ding, S. T. (2018). Adiponectin and adiponectin receptor 1 overexpression enhance inflammatory bowel disease. Journal of biomedical science, 25(1), 1-13.

Kim, M. W., Bin Abid, N., Jo, M. H., Jo, M. G., Yoon, G. H., & Kim, M. O. (2017). Suppression of adiponectin receptor 1 promotes memory dysfunction and Alzheimer’s disease-like pathologies. Scientific reports, 7(1), 1-10.

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For research use only. Not intended for any clinical use.

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