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Mouse Anti-ADNP Recombinant Antibody (V2-12529) (CBMAB-1019-CN)

This product is a mouse antibody that recognizes ADNP of human. The antibody 2C5 can be used for immunoassay techniques such as: WB, IF, ELISA.
See all ADNP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-12529
Antibody Isotype
IgG2a
Application
WB, IF, ELISA

Basic Information

Immunogen
ADNP (NP_056154, aa. 1018-1102) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)10 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Activity Dependent Neuroprotector Homeobox
Introduction
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This protein is a potential transcription factor. The protein may mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.
Entrez Gene ID
23394
UniProt ID
Q9H2P0
Alternative Names
ADNP1; HVDAS; MRD28
Function
Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.
Biological Process
Regulation of gene expression
Cellular Location
Nucleus
Involvement in disease
Helsmoortel-van der Aa syndrome (HVDAS): A disorder characterized by intellectual disability, autism spectrum disorder, and dysmorphic facial features including prominent forehead, high hairline, downslanting palpebral fissures, notched eyelids, broad nasal bridge, thin upper lip, and smooth philtrum.

Theune, W. (2021). Using Zebrafish as a Model System for Studying the Autism Risk Gene adnp in Early Embryonic Development.

Van Dijck, A., Vandeweyer, G., & Kooy, F. (2021). ADNP-Related Disorder. In GeneReviews®[Internet]. University of Washington, Seattle.

Turashvili, G. (2020). ADNP (Activity Dependent Neuroprotector Homeobox): A novel oncogene driving poor prognosis in high-grade serous carcinoma. EBioMedicine, 51.

Shillington, A., Pedapati, E., Hopkin, R., & Suhrie, K. (2020). Early behavioral and developmental interventions in ADNP‐syndrome: A case report of SWI/SNF‐related neurodevelopmental syndrome. Molecular genetics & genomic medicine, 8(6), e1230.

Bend, E. G., Aref-Eshghi, E., Everman, D. B., Rogers, R. C., Cathey, S. S., Prijoles, E. J., ... & Sadikovic, B. (2019). Gene domain-specific DNA methylation episignatures highlight distinct molecular entities of ADNP syndrome. Clinical epigenetics, 11(1), 1-17.

Karagoz, K., Mehta, G. A., Khella, C. A., Khanna, P., & Gatza, M. L. (2019). Integrative proteogenomic analyses of human tumours identifies ADNP as a novel oncogenic mediator of cell cycle progression in high-grade serous ovarian cancer with poor prognosis. EBioMedicine, 50, 191-202.

Kapitansky, O., & Gozes, I. (2019). ADNP differentially interact with genes/proteins in correlation with aging: a novel marker for muscle aging. Geroscience, 41(3), 321-340.

Arnett, A. B., Rhoads, C. L., Hoekzema, K., Turner, T. N., Gerdts, J., Wallace, A. S., ... & Bernier, R. A. (2018). The autism spectrum phenotype in ADNP syndrome. Autism Research, 11(9), 1300-1310.

Medina, G. N., Knudsen, G. M., Greninger, A. L., Kloc, A., Díaz-San Segundo, F., Rieder, E., ... & de Los Santos, T. (2017). Interaction between FMDV Lpro and transcription factor ADNP is required for optimal viral replication. Virology, 505, 12-22.

Takenouchi, T., Miwa, T., Sakamoto, Y., Sakaguchi, Y., Uehara, T., Takahashi, T., & Kosaki, K. (2017). Further evidence that a blepharophimosis syndrome phenotype is associated with a specific class of mutation in the ADNP gene. American journal of medical genetics Part A, 173(6), 1631-1634.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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