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Mouse Anti-ADNP Recombinant Antibody (V2-180000) (CBMAB-A1386-YC)

Provided herein is a Mouse monoclonal antibody against Human Activity Dependent Neuroprotector Homeobox. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all ADNP antibodies
Published Data
Mouse Anti-ADNP Recombinant Antibody (F-5) (CBMAB-A1386-YC) in WB
ADNP protein levels in brain of Dp(16)1Yey mice. Western blotting showing ADNP in brain of control (WT) and Dp(16)1Yey mice. Values were obtained by normalization of images from ADNP to βactin (for Western blot) or Ponceau-S coloration (for slot blot). Statistical analysis was done with the Student's t-test using Statview software. Data were normalized to the mean of control (WT) mice. The results are represented as means ± SEM. n = number of mice. * p < 0.05. ...View More
Moreau, M., Carmona-Iragui, M., Altuna, M., Dalzon, L., Barroeta, I., Vilaire, M., ... & Janel, N. (2022). DYRK1A and Activity-Dependent Neuroprotective Protein Comparative Diagnosis Interest in Cerebrospinal Fluid and Plasma in the Context of Alzheimer-Related Cognitive Impairment in Down Syndrome Patients. Biomedicines, 10(6), 1380.
Mouse Anti-ADNP Recombinant Antibody (F-5) (CBMAB-A1386-YC) in WB
Lysates were prepared from LF-PK cells mock transfected (lane 1) or transfected with siAll Star (lanes 2-3) or siADNP (lanes 4-5) and ADNP was detected by western blot. Separate bottom panel shows detection of tubulin to ensure that equal amounts of protein were applied to each lane. ...View More
Medina, G. N., Knudsen, G. M., Greninger, A. L., Kloc, A., Díaz-San Segundo, F., Rieder, E., ... & de Los Santos, T. (2017). Interaction between FMDV Lpro and transcription factor ADNP is required for optimal viral replication. Virology, 505, 12-22.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
V2-180000
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Raised against amino acids 1-138 mapping at the N-terminus of ADNP of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate).
IF(ICC)1:50-1:500
ELISA1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 0.1% gelatin.
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Activity Dependent Neuroprotector Homeobox
Introduction
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be invol
Entrez Gene ID
Human23394
Mouse11538
Rat64622
UniProt ID
HumanQ9H2P0
MouseQ9Z103
RatQ9JKL8
Alternative Names
Activity Dependent Neuroprotector Homeobox; Activity-Dependent Neuroprotective Protein; Activity-Dependent Neuroprotector; ADNP Homeobox 1; ADNP1; Activity-Dependent Neuroprotector Homeobox Protein; KIAA0784; HVDAS; MRD28;
Function
Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.
Biological Process
Regulation of gene expression
Cellular Location
Nucleus
Involvement in disease
Helsmoortel-van der Aa syndrome (HVDAS): A disorder characterized by intellectual disability, autism spectrum disorder, and dysmorphic facial features including prominent forehead, high hairline, downslanting palpebral fissures, notched eyelids, broad nasal bridge, thin upper lip, and smooth philtrum.

Theune, W. (2021). Using Zebrafish as a Model System for Studying the Autism Risk Gene adnp in Early Embryonic Development.

Van Dijck, A., Vandeweyer, G., & Kooy, F. (2021). ADNP-Related Disorder. In GeneReviews®[Internet]. University of Washington, Seattle.

Turashvili, G. (2020). ADNP (Activity Dependent Neuroprotector Homeobox): A novel oncogene driving poor prognosis in high-grade serous carcinoma. EBioMedicine, 51.

Shillington, A., Pedapati, E., Hopkin, R., & Suhrie, K. (2020). Early behavioral and developmental interventions in ADNP‐syndrome: A case report of SWI/SNF‐related neurodevelopmental syndrome. Molecular genetics & genomic medicine, 8(6), e1230.

Bend, E. G., Aref-Eshghi, E., Everman, D. B., Rogers, R. C., Cathey, S. S., Prijoles, E. J., ... & Sadikovic, B. (2019). Gene domain-specific DNA methylation episignatures highlight distinct molecular entities of ADNP syndrome. Clinical epigenetics, 11(1), 1-17.

Karagoz, K., Mehta, G. A., Khella, C. A., Khanna, P., & Gatza, M. L. (2019). Integrative proteogenomic analyses of human tumours identifies ADNP as a novel oncogenic mediator of cell cycle progression in high-grade serous ovarian cancer with poor prognosis. EBioMedicine, 50, 191-202.

Kapitansky, O., & Gozes, I. (2019). ADNP differentially interact with genes/proteins in correlation with aging: a novel marker for muscle aging. Geroscience, 41(3), 321-340.

Arnett, A. B., Rhoads, C. L., Hoekzema, K., Turner, T. N., Gerdts, J., Wallace, A. S., ... & Bernier, R. A. (2018). The autism spectrum phenotype in ADNP syndrome. Autism Research, 11(9), 1300-1310.

Medina, G. N., Knudsen, G. M., Greninger, A. L., Kloc, A., Díaz-San Segundo, F., Rieder, E., ... & de Los Santos, T. (2017). Interaction between FMDV Lpro and transcription factor ADNP is required for optimal viral replication. Virology, 505, 12-22.

Takenouchi, T., Miwa, T., Sakamoto, Y., Sakaguchi, Y., Uehara, T., Takahashi, T., & Kosaki, K. (2017). Further evidence that a blepharophimosis syndrome phenotype is associated with a specific class of mutation in the ADNP gene. American journal of medical genetics Part A, 173(6), 1631-1634.

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For research use only. Not intended for any clinical use.

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