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Mouse Anti-AGRP Recombinant Antibody (V2-180226) (CBMAB-A1654-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180226
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human AgRP Ala21-Thr132.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Agouti Related Neuropeptide
Introduction
AGRP is an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutati
Entrez Gene ID
181
UniProt ID
O00253
Alternative Names
Agouti Related Neuropeptide; AGRT; ART; Agouti Related Protein Homolog (Mouse); Agouti (Mouse) Related Protein; Agouti Related Protein Homolog; Agouti-Related Protein; ASIP2;
Biological Process
Adult feeding behavior
Circadian rhythm
Eating behavior
Feeding behavior
Hormone-mediated signaling pathway
Long-day photoperiodism
Maternal process involved in female pregnancy
Neuropeptide signaling pathway
Positive regulation of feeding behavior
Regulation of feeding behavior
Response to insulin
Cellular Location
Secreted; Golgi apparatus lumen
Involvement in disease
Obesity (OBESITY): A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
More Infomation

Loganathan, N. (2021). Molecular mechanisms involved in the regulation of agouti-related peptide and neuropeptide Y by endocrine disrupting chemical bisphenol A in hypothalamic neurons (Doctoral dissertation, University of Toronto (Canada)).

Qiu, J., Bosch, M. A., Zhang, C., Rønnekleiv, O. K., & Kelly, M. J. (2020). Estradiol protects neuropeptide Y/agouti-related peptide neurons against insulin resistance in females. Neuroendocrinology, 110(1-2), 105-118.

Kalananthan, T., Murashita, K., Rønnestad, I., Ishigaki, M., Takahashi, K., Silva, M. S., ... & Gomes, A. S. (2020). Hypothalamic agrp and pomc mRNA Responses to Gastrointestinal Fullness and Fasting in Atlantic Salmon (Salmo salar, L.). Frontiers in physiology, 11, 61.

Jiang, J., Morgan, D. A., Cui, H., & Rahmouni, K. (2020). Activation of hypothalamic AgRP and POMC neurons evokes disparate sympathetic and cardiovascular responses. American Journal of Physiology-Heart and Circulatory Physiology, 319(5), H1069-H1077.

Chen, Y., Essner, R. A., Kosar, S., Miller, O. H., Lin, Y. C., Mesgarzadeh, S., & Knight, Z. A. (2019). Sustained NPY signaling enables AgRP neurons to drive feeding. Elife, 8, e46348.

Wu, J., Zhu, C., Yang, L., Wang, Z., Wang, L., Wang, S., ... & Shu, G. (2017). N-oleoylglycine-induced hyperphagia is associated with the activation of agouti-related protein (AgRP) neuron by cannabinoid receptor type 1 (CB1R). Journal of agricultural and food chemistry, 65(5), 1051-1057.

Chen, S. R., Chen, H., Zhou, J. J., Pradhan, G., Sun, Y., Pan, H. L., & Li, D. P. (2017). Ghrelin receptors mediate ghrelin‐induced excitation of agouti‐related protein/neuropeptide Y but not pro‐opiomelanocortin neurons. Journal of neurochemistry, 142(4), 512-520.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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