Rabbit Anti-AGTR1 Recombinant Antibody (
4A9) (V2LY-0725-LY1125)

Name: Rabbit Anti-AGTR1 Recombinant Antibody (4A9)
SKU: V2LY-0725-LY1125
Rating: 5 (1 reviews)

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Tested Data

Rabbit Anti-AGTR1 Recombinant Antibody (4A9) (V2LY-0725-LY1125) in WB

Western Blot
Positive WB detected in: Hela whole cell lysate, Raji whole cell lysate, MCF-7 whole cell lysate
All lanes: AGTR1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 42 kDa
Observed band size: 42 kDa

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

4A9

Application

ELISA, WB

Immunogen

A synthesized peptide derived from human AGTR1.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:5,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Angiotensin II Receptor Type 1

Entrez Gene ID

185

UniProt ID

P30556

Function

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Biological Process

Angiotensin-activated signaling pathway
Blood vessel diameter maintenance
Calcium-mediated signaling
Cell chemotaxis
G protein-coupled receptor signaling pathway
Inflammatory response
Kidney development
Low-density lipoprotein particle remodeling
Maintenance of blood vessel diameter homeostasis by renin-angiotensin
Phospholipase C-activating angiotensin-activated signaling pathway
Phospholipase C-activating G protein-coupled receptor signaling pathway
Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Positive regulation of cellular protein metabolic process
Positive regulation of cholesterol esterification
Positive regulation of cytosolic calcium ion concentration
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
Positive regulation of inflammatory response
Positive regulation of macrophage derived foam cell differentiation
Positive regulation of NAD(P)H oxidase activity
Positive regulation of phospholipase A2 activity
Positive regulation of reactive oxygen species metabolic process
Regulation of cell growth
Regulation of cell population proliferation
Regulation of inflammatory response
Regulation of renal sodium excretion
Regulation of systemic arterial blood pressure by renin-angiotensin
Regulation of vasoconstriction
Renin-angiotensin regulation of aldosterone production
Rho protein signal transduction

Cellular Location

Cell membrane

Involvement in disease

Renal tubular dysgenesis (RTD): Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).

Topology

Extracellular: 1-27 aa
Helical: 28-52 aa
Cytoplasmic: 53-64 aa
Helical: 65-87 aa
Extracellular: 88-102 aa
Helical: 103-124 aa
Cytoplasmic: 125-142 aa
Helical: 143-162 aa
Extracellular: 163-192 aa
Helical: 193-214 aa
Cytoplasmic: 215-240 aa
Helical: 241-262 aa
Extracellular: 263-275 aa
Helical: 276-296 aa
Cytoplasmic: 297-359 aa

PTM

C-terminal Ser or Thr residues may be phosphorylated.

Viering, D. H., Bech, A. P., de Baaij, J. H., Steenbergen, E. J., Danser, A. J., Wetzels, J. F., ... & Deinum, J. (2021). Functional tests to guide management in an adult with loss of function of type-1 angiotensin II receptor. Pediatric Nephrology, 1-7.

Zhang, Z., Yuan, Y., He, L., Yao, X., & Chen, J. (2020). Involvement of angiotensin II receptor type 1/NF‑κB signaling in the development of endometriosis. Experimental and therapeutic medicine, 20(4), 3269-3277.

Junusbekov, Y., Bayoglu, B., Cengiz, M., Dirican, A., & Arslan, C. (2020). AGT rs699 and AGTR1 rs5186 gene variants are associated with cardiovascular-related phenotypes in atherosclerotic peripheral arterial obstructive disease. Irish Journal of Medical Science (1971-), 189(3), 885-894.

Li, X., Wu, N., Ji, H., Huang, Y., Hu, H., Li, J., ... & Chen, X. (2020). A male-specific association between AGTR1 hypermethylation and coronary heart disease. Bosnian journal of basic medical sciences, 20(1), 31.

Zhang, K., Wiedemann, S., Dschietzig, M., Cremers, M. M., Augstein, A., Poitz, D. M., ... & Heidrich, F. M. (2020). The infarction zone rather than the noninfarcted remodeling zone overexpresses angiotensin II receptor type 1 and is the main source of ventricular atrial natriuretic peptide. Cardiovascular Pathology, 44, 107160.

Aoyagi, Y., Furuyama, T., Inoue, K., Matsuda, D., Matsubara, Y., Okahara, A., ... & Matsumoto, T. (2019). Attenuation of Angiotensin II–Induced Hypertension in BubR1 Low‐Expression Mice Via Repression of Angiotensin II Receptor 1 Overexpression. Journal of the American Heart Association, 8(23), e011911.

Zhao, Y., Xu, K., & Liu, P. (2018). Post-transcriptional control of angiotensin II type 1 receptor regulates osteosarcoma cell death. Cellular Physiology and Biochemistry, 45(4), 1581-1589.

Kim, J. Y., Oh, E., Kim, Y. J., Sung, D., Cho, T. M., Jang, S., & Seo, J. H. (2018). Blockage of angiotensin II type 1 receptor (AGTR1) inhibits epithelial-mesenchymal transition (EMT) and tumor growth in breast cancer.

Zhuang, Y., Niu, F., Liu, D., Sun, J., Zhang, X., Zhang, J., & Guo, S. (2018). Association between AGTR1 A1166C polymorphism and the susceptibility to diabetic nephropathy: Evidence from a meta-analysis. Medicine, 97(41).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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