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Mouse Anti-AIP Recombinant Antibody (V2-630614) (CBMAB-BR013LY)

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Datasheet
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
V2-630614
Application
FC, IF, IHC-P, ICC, WB
Immunogen
E.coli-derived human ARA9 recombinant protein (Position: D91-H330)
Host Species
Mouse
Specificity
Human, Monkey, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB0.1-0.5 μg/ml
IHC-P0.5-1 μg/ml
IF(ICC)2 μg/ml
FC1-3 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
0.05 mg sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
aryl hydrocarbon receptor interacting protein
Introduction
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Entrez Gene ID
Human9049
Mouse11632
Rat282827
Monkey711814
UniProt ID
HumanO00170
MouseO08915
RatQ5FWY5
MonkeyO97628
Alternative Names
H receptor-interacting protein; AIP; Aryl-hydrocarbon receptor-interacting protein; HBV X-associated protein 2; XAP-2; Immunophilin homolog ARA9; AIP; XAP2
Function
May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
Cellular negative regulator of the hepatitis B virus (HBV) X protein.
Biological Process
Interleukin-12-mediated signaling pathway Source: Reactome
Negative regulation of cyclic-nucleotide phosphodiesterase activity Source: Ensembl
Protein maturation by protein folding Source: HGNC-UCL
Protein targeting to mitochondrion Source: HGNC-UCL
Regulation of protein kinase A signaling Source: Ensembl
Xenobiotic metabolic process Source: Reactome
Cellular Location
Cytoplasm
Involvement in disease
Pituitary adenoma 1, multiple types (PITA1): A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete: growth hormone (GH)-secreting, prolactin (PRL)-secreting, adrenocorticotropin (ACTH)-secreting, thyroid- stimulating hormone (TSH)-secreting, and plurihormonal (GH and TSH) tumors. Familial and sporadic forms have been reported.
Prolactin-secreting pituitary adenoma (PSPA): Most common type of hormonally active pituitary adenoma.

Fernández-Aceñero, M. J., Barderas, R., García, A. P., Martínez-Useros, J., Díez-Valladares, L., Medina, L. O., ... & Galindo, C. (2021). Aryl hydrocarbon receptor interacting protein (AIP) significantly influences prognosis of pancreatic carcinoma. Annals of Diagnostic Pathology, 53, 151742.

Gunin, A. G., & Golubtzova, N. N. (2021). Aryl Hydrocarbon Receptor-Interacting Protein (AIP) in the Human Dermis with Aging. Advances in Gerontology, 11(1), 59-63.

Feola, T., Capelli, R., Gianno, F., Compagnoni, C., Letizia, C., De Toma, G., ... & Marie-Lise, J. R. (2021, May). Aryl hydrocarbon receptor Interacting Protein (AIP) status in a functional adrenal adenoma occurring in a patient with a germline AIP mutation. In Endocrine Abstracts (Vol. 73). Bioscientifica.

Del Arco, C. D., Muñoz, L. E., Manchado, R. B., García, A. P., Medina, L. O., Roldán, E. M., ... & Aceñero, M. J. F. (2020). Prognostic Role of Aryl Hydrocarbon Receptor Interacting Protein (AIP) Immunohistochemical Expression in Patients with Resected Gastric Carcinomas. Pathology & Oncology Research, 26(4), 2641-2650.

Cai, F., Hong, Y., Xu, J., Wu, Q., Reis, C., Yan, W., ... & Zhang, J. (2019). A novel mutation of Aryl hydrocarbon receptor interacting protein gene associated with familial isolated pituitary adenoma mediates tumor invasion and growth hormone hypersecretion. World neurosurgery, 123, e45-e59.

Sun, D., Stopka-Farooqui, U., Barry, S., Aksoy, E., Parsonage, G., Vossenkämper, A., ... & Haworth, O. (2019). Aryl hydrocarbon receptor interacting protein maintains germinal center B cells through suppression of BCL6 degradation. Cell reports, 27(5), 1461-1471.

Stojanovic, M., Wu, Z., Stiles, C. E., Miljic, D., Soldatovic, I., Pekic, S., ... & Korbonits, M. (2019). Circulating aryl hydrocarbon receptor-interacting protein (AIP) is independent of GH secretion. Endocrine connections, 8(4), 326-337.

Ozkaya, H. M., Comunoglu, N., Sayitoglu, M., Keskin, F. E., Firtina, S., Khodzhaev, K., ... & Kadioglu, P. (2018). Germline mutations of aryl hydrocarbon receptor-interacting protein (AIP) gene and somatostatin receptor 1–5 and AIP immunostaining in patients with sporadic acromegaly with poor versus good response to somatostatin analogues. Pituitary, 21(4), 335-346.

Hernández-Ramírez, L. C., Trivellin, G., & Stratakis, C. A. (2017). Role of phosphodiesterases on the function of aryl hydrocarbon receptor-interacting protein (AIP) in the pituitary gland and on the evaluation of AIP gene variants. Hormone and Metabolic Research, 49(04), 286-295.

Formosa, R., & Vassallo, J. (2017). Aryl hydrocarbon receptor–interacting protein (AIP) N-terminus gene mutations identified in pituitary adenoma patients alter protein stability and function. Hormones and Cancer, 8(3), 174-184.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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