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Mouse Anti-AKAP6 Recombinant Antibody (V2-611077) (CBMAB-A0230-LY)

The product is antibody recognizes AKAP6. The antibody 1E7 immunoassay techniques such as: sELISA, ELISA.
See all AKAP6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-611077
Antibody Isotype
IgG2a, κ
Application
SELISA, ELISA

Basic Information

Immunogen
AKAP6 (NP_004265.3, 2221 a.a. ~ 2318 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
A kinase (PRKA) anchor protein 6
Introduction
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq]
Entrez Gene ID
9472
UniProt ID
Q13023
Alternative Names
ADAP100; ADAP6; AKAP100; KIAA0311; MGC165020; PRKA6; mAKAP
Function
Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.
Biological Process
Action potential Source: BHF-UCL
cAMP-mediated signaling Source: BHF-UCL
Cellular response to cAMP Source: BHF-UCL
Cellular response to cytokine stimulus Source: BHF-UCL
Positive regulation of calcineurin-NFAT signaling cascade Source: BHF-UCL
Positive regulation of cell growth Source: BHF-UCL
Positive regulation of cell growth involved in cardiac muscle cell development Source: BHF-UCL
Positive regulation of delayed rectifier potassium channel activity Source: BHF-UCL
Positive regulation of potassium ion transmembrane transport Source: BHF-UCL
Positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
Positive regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Protein targeting Source: UniProtKB
Regulation of membrane repolarization Source: BHF-UCL
Regulation of protein kinase A signaling Source: BHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
Cellular Location
Nucleus membrane; Sarcoplasmic reticulum. In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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