Mouse Anti-ALDH1A3 Recombinant Antibody (4B6) (CBMAB-A2257-YC)

Name: Mouse Anti-ALDH1A3 Recombinant Antibody (4B6)
SKU: CBMAB-A2257-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4B6

Application

IHC, WB, IF, ICC

Immunogen

This antibody was developed against a synthetic peptide.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1 µg/ml
IF(ICC)	2-10 µg/ml
IHC-P	1:1,000-1:2,500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2, 40% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Aldehyde Dehydrogenase 1 Family Member A3

Introduction

ALDH1A3 is an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells.

Entrez Gene ID

220

UniProt ID

P47895

Alternative Names

Aldehyde Dehydrogenase 1 Family Member A3; Retinaldehyde Dehydrogenase 3; Aldehyde Dehydrogenase 6; RALDH3; ALDH6; Aldehyde Dehydrogenase 1 Family, Member A3; Aldehyde Dehydrogenase Family 1 Member A3;

Function

NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid (PubMed:27759097). Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde (PubMed:27759097). Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region (By similarity).

Biological Process

Embryonic camera-type eye development Source: UniProtKB
Embryonic eye morphogenesis Source: UniProtKB
Face development Source: Ensembl
Harderian gland development Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Locomotory behavior Source: Ensembl
Neuromuscular process controlling balance Source: Ensembl
Nucleus accumbens development Source: Ensembl
Olfactory pit development Source: Ensembl
Optic cup morphogenesis involved in camera-type eye development Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Protein homotetramerization Source: UniProtKB
Retinal metabolic process Source: UniProtKB
Retinoic acid biosynthetic process Source: UniProtKB
Retinoic acid metabolic process Source: UniProtKB
Retinol metabolic process Source: UniProtKB-UniPathway
Righting reflex Source: Ensembl

Cellular Location

Cytoplasm

Involvement in disease

Microphthalmia, isolated, 8 (MCOP8): A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present.

Wong, W. R., Maher, S., Oh, J. Y., Brugman, K. I., Gharib, S., & Sternberg, P. W. (2021). Conserved missense variant in ALDH1A3 ortholog impairs fecundity in C. elegans. microPublication Biology, 2021.

Pan, M., Li, M., Guo, M., Zhou, H., Xu, H., Zhao, F., ... & Dou, J. (2021). Knockdown of ALDH1A3 reduces breast cancer stem cell marker CD44 via the miR‑7‑TGFBR2‑Smad3‑CD44 regulatory axis. Experimental and Therapeutic Medicine, 22(4), 1-8.

Cheng, M., Duan, P. G., Gao, Z. Z., & Dai, M. (2020). MicroRNA‑487b‑3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3. Oncology Reports, 44(6), 2691-2700.

Nie, S., Qian, X., Shi, M., Li, H., Peng, C., Ding, X., ... & Shen, S. (2020). ALDH1A3 accelerates pancreatic Cancer metastasis by promoting glucose metabolism. Frontiers in oncology, 10, 915.

Li, D., Zhao, Z., Shao, N., Hennigs, J., Miyagawa, K., & Rabinovitch, M. (2017). ALDH1A3 Regulates Chromatin Remodeling and Smooth Muscle Proliferative Genes in PAH. Circulation, 136(suppl_1), A15944-A15944.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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