Mouse Recombinant ALDH1A3 protein, His Tag (V2LY-0526-LY7789)

Name: Mouse Recombinant ALDH1A3 protein, His Tag
SKU: V2LY-0526-LY7789
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant ALDH1A3 protein, His Tag consist of Amino Acid: 2-512 and predicts a molecular mass of 56.94 kDa.

Molecule Mass

56.94 kDa

Sequence

Amino Acid: 2-512

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Aldehyde Dehydrogenase 1 Family Member A3

Function

NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid (PubMed:27759097). Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde (PubMed:27759097). Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region (By similarity).

Biological Process

Embryonic camera-type eye development Source: UniProtKB
Embryonic eye morphogenesis Source: UniProtKB
Face development Source: Ensembl
Harderian gland development Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Locomotory behavior Source: Ensembl
Neuromuscular process controlling balance Source: Ensembl
Nucleus accumbens development Source: Ensembl
Olfactory pit development Source: Ensembl
Optic cup morphogenesis involved in camera-type eye development Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Protein homotetramerization Source: UniProtKB
Retinal metabolic process Source: UniProtKB
Retinoic acid biosynthetic process Source: UniProtKB
Retinoic acid metabolic process Source: UniProtKB
Retinol metabolic process Source: UniProtKB-UniPathway
Righting reflex Source: Ensembl

Cellular Location

Cytoplasm

Involvement in disease

Microphthalmia, isolated, 8 (MCOP8): A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present.

Wong, W. R., Maher, S., Oh, J. Y., Brugman, K. I., Gharib, S., & Sternberg, P. W. (2021). Conserved missense variant in ALDH1A3 ortholog impairs fecundity in C. elegans. microPublication Biology, 2021.

Pan, M., Li, M., Guo, M., Zhou, H., Xu, H., Zhao, F., ... & Dou, J. (2021). Knockdown of ALDH1A3 reduces breast cancer stem cell marker CD44 via the miR‑7‑TGFBR2‑Smad3‑CD44 regulatory axis. Experimental and Therapeutic Medicine, 22(4), 1-8.

Cheng, M., Duan, P. G., Gao, Z. Z., & Dai, M. (2020). MicroRNA‑487b‑3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3. Oncology Reports, 44(6), 2691-2700.

Nie, S., Qian, X., Shi, M., Li, H., Peng, C., Ding, X., ... & Shen, S. (2020). ALDH1A3 accelerates pancreatic Cancer metastasis by promoting glucose metabolism. Frontiers in oncology, 10, 915.

Li, D., Zhao, Z., Shao, N., Hennigs, J., Miyagawa, K., & Rabinovitch, M. (2017). ALDH1A3 Regulates Chromatin Remodeling and Smooth Muscle Proliferative Genes in PAH. Circulation, 136(suppl_1), A15944-A15944.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ALDH1A3 protein, His Tag (CAT#: V2LY-0526-LY1998)

Related Products

Mouse Anti-ALDH1A3 Recombinant Antibody (GT926) (CAT#: CBMAB-A2255-YC)

Human Recombinant ALDH1A3 protein, His Tag (CAT#: V2LY-0526-LY1998)

Mouse Anti-ALDH1A3 Recombinant Antibody (4B6) (CAT#: CBMAB-A2257-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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