Human ALDH1A3 ELISA Kit (V2LY-0626-LY4328)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0073 ng/mL
Detection Range
0.015-3 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
56.1 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Aldehyde Dehydrogenase 1 Family Member A3
Function
NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid (PubMed:27759097). Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde (PubMed:27759097). Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region (By similarity).
Biological Process
Embryonic camera-type eye development Source: UniProtKB
Embryonic eye morphogenesis Source: UniProtKB
Face development Source: Ensembl
Harderian gland development Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Locomotory behavior Source: Ensembl
Neuromuscular process controlling balance Source: Ensembl
Nucleus accumbens development Source: Ensembl
Olfactory pit development Source: Ensembl
Optic cup morphogenesis involved in camera-type eye development Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Protein homotetramerization Source: UniProtKB
Retinal metabolic process Source: UniProtKB
Retinoic acid biosynthetic process Source: UniProtKB
Retinoic acid metabolic process Source: UniProtKB
Retinol metabolic process Source: UniProtKB-UniPathway
Righting reflex Source: Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Microphthalmia, isolated, 8 (MCOP8): A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present.

Wong, W. R., Maher, S., Oh, J. Y., Brugman, K. I., Gharib, S., & Sternberg, P. W. (2021). Conserved missense variant in ALDH1A3 ortholog impairs fecundity in C. elegans. microPublication Biology, 2021.

Pan, M., Li, M., Guo, M., Zhou, H., Xu, H., Zhao, F., ... & Dou, J. (2021). Knockdown of ALDH1A3 reduces breast cancer stem cell marker CD44 via the miR‑7‑TGFBR2‑Smad3‑CD44 regulatory axis. Experimental and Therapeutic Medicine, 22(4), 1-8.

Cheng, M., Duan, P. G., Gao, Z. Z., & Dai, M. (2020). MicroRNA‑487b‑3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3. Oncology Reports, 44(6), 2691-2700.

Nie, S., Qian, X., Shi, M., Li, H., Peng, C., Ding, X., ... & Shen, S. (2020). ALDH1A3 accelerates pancreatic Cancer metastasis by promoting glucose metabolism. Frontiers in oncology, 10, 915.

Li, D., Zhao, Z., Shao, N., Hennigs, J., Miyagawa, K., & Rabinovitch, M. (2017). ALDH1A3 Regulates Chromatin Remodeling and Smooth Muscle Proliferative Genes in PAH. Circulation, 136(suppl_1), A15944-A15944.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ALDH1A3 protein, His Tag (CAT#: V2LY-0526-LY1998)

Mouse Recombinant ALDH1A3 protein, His Tag (CAT#: V2LY-0526-LY7789)

Related Products

Mouse Anti-ALDH1A3 Recombinant Antibody (4B6) (CAT#: CBMAB-A2257-YC)

Mouse Anti-ALDH1A3 Recombinant Antibody (GT926) (CAT#: CBMAB-A2255-YC)

Mouse Recombinant ALDH1A3 protein, His Tag (CAT#: V2LY-0526-LY7789)

Human Recombinant ALDH1A3 protein, His Tag (CAT#: V2LY-0526-LY1998)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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