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Mouse Anti-ALDH4A1 Recombinant Antibody (1A12-A5) (CBMAB-A2296-YC)

Provided herein is a Mouse monoclonal antibody against Human Aldehyde Dehydrogenase 4 Family Member A1. The antibody can be used for immunoassay techniques, such as ELISA, IHC, WB.
See all ALDH4A1 antibodies
Published Data
Mouse Anti-ALDH4A1 Recombinant Antibody (1A12-A5) in IHC and IF
Localization of ALDH4A1 in the postmortem brain. The localization of ALDH4A1 in the gray matter of the prefrontal cortex of the postmortem brain from healthy control. (A) The image of gray matter tissues immunostained for anti-ALDH4A1 antibodies.Immunopositive neuron was indicated by the arrow. Immnopositive astrocyte was indicated by the arrowhead. Immunopositive dots were scattered in the area of neuropil (circle). Scale bar, 20 μm. (B) Immunofluorescence images showed the location of ALDH4A1 (green) and mitochondria labeled with anti-COX antibodies (red). The arrowheads indicated the co-localization of ALDH4A1 with mitochondria. Scale bar, 20 μm. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.) ...View More
Nagaoka, A., Kunii, Y., Hino, M., Izumi, R., Nagashima, C., Takeshima, A., ... & Yabe, H. (2020). ALDH4A1 expression levels are elevated in postmortem brains of patients with schizophrenia and are associated with genetic variants in enzymes related to proline metabolism. Journal of Psychiatric Research, 123, 119-127.

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A12-A5
Antibody Isotype
IgG1, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-564 from ALDH4A1 (AAH07581) with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC-P5 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Aldehyde Dehydrogenase 4 Family Member A1
Introduction
ALDH4A1 belongs to the aldehyde dehydrogenase family of proteins. ALDH4A1 is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency
Entrez Gene ID
8659
UniProt ID
P30038
Alternative Names
Aldehyde Dehydrogenase 4 Family Member A1; L-Glutamate Gamma-Semialdehyde Dehydrogenase; Aldehyde Dehydrogenase Family 4 Member A1; P5C Dehydrogenase; ALDH4; P5CDh; Delta-1-Pyrroline-5-Carboxylate Dehydrogenase, Mitochondrial;
Function
Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
Biological Process
4-hydroxyproline catabolic process Source: BHF-UCL
Glyoxylate metabolic process Source: Reactome
Proline catabolic process Source: Reactome
Proline catabolic process to glutamate Source: UniProtKB-UniPathway
Proline metabolic process Source: ProtInc
Cellular Location
Mitochondrion matrix
Involvement in disease
Hyperprolinemia 2 (HYRPRO2): An inborn error of proline metabolism resulting in elevated plasma levels of proline and delta-1-pyrroline-5-carboxylate (P5C). The condition is considered to be benign, but affected individuals can exhibit neurological manifestations that vary in severity. Clinical signs include seizures, intellectual deficit and mild developmental delay.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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