Mouse Anti-ALDH7A1 Recombinant Antibody (C4) (CBMAB-AP268LY)

Name: Mouse Anti-ALDH7A1 Recombinant Antibody (C4)
SKU: CBMAB-AP268LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

Application

WB, IP, IF, ELISA, IHC-P

Immunogen

Amino acids 489-506 at the C-terminus of Antiquitin of human origin.

Host Species

Mouse

Specificity

Human, Avian

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:30-1:3,000
IHC	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Aldehyde Dehydrogenase 7 Family Member A1

Introduction

The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified. [provided by RefSeq, Jan 2011]

Entrez Gene ID

501

UniProt ID

P49419

Alternative Names

Aldehyde Dehydrogenase 7 Family Member A1; Alpha-AASA Dehydrogenase; P6c Dehydrogenase; Delta1-Piperideine-6-Carboxylate Dehydrogenase; Alpha-Aminoadipic Semialdehyde Dehydrogenase; Betaine Aldehyde Dehydrogenase; 26g Turgor Protein Homolog; Antiquitin-1; ATQ1; Delta1-Piperideine-6-Carboxylate Dehydrogenease;

Function

Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.

Biological Process

Cellular aldehyde metabolic process Source: UniProtKB
Choline catabolic process Source: Reactome
Glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway
Lysine catabolic process Source: Reactome
Sensory perception of sound Source: ProtInc

Cellular Location

Nucleus; Cytosol
Isoform 1: Mitochondrion

Involvement in disease

Pyridoxine-dependent epilepsy (PDE): Characterized by a combination of various seizure types. It usually occurs in the first hours of life and is unresponsive to standard anticonvulsants, responding only to immediate administration of pyridoxine hydrochloride.

Tan, M., Meng, J., Sun, X., Fu, X., & Wang, R. (2021). EPS8 supports pancreatic cancer growth by inhibiting BMI1 mediated proteasomal degradation of ALDH7A1. Experimental Cell Research, 112782.

Li, X., Fan, K., Liu, Y., Liu, Y., & Liu, P. F. (2021). Administration of a recombinant ALDH7A1 (rA7) indicates potential regulation of the metabolite and immunology pathways in Atlantic salmon infected with Aeromonas salmonicida. Journal of Fish Diseases, 44(7), 961-977.

Laciak, A. R., Korasick, D. A., Wyatt, J. W., Gates, K. S., & Tanner, J. J. (2020). Structural and biochemical consequences of pyridoxine‐dependent epilepsy mutations that target the aldehyde binding site of aldehyde dehydrogenase ALDH 7A1. The FEBS journal, 287(1), 173-189.

Faust, T. E. (2018). NOVEL MECHANISMS OF ALDEHYDE DEHYDROGENASE 7 FAMILY MEMBER A1 (ALDH7A1) IN THE BRAIN: ASTROCYTES, EXCITATORY-INHIBITORY BALANCE, AND BEHAVIORS (Doctoral dissertation, Johns Hopkins University).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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