Human Recombinant ALDH7A1 protein, His Tag (V2LY-0526-LY2002)

Name: Human Recombinant ALDH7A1 protein, His Tag
SKU: V2LY-0526-LY2002
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant ALDH7A1 protein, His Tag consist of Amino Acid: 2-511 and predicts a molecular mass of 56 kDa.

Molecule Mass

56 kDa

Sequence

Amino Acid: 2-511

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>93% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, DTT, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Aldehyde Dehydrogenase 7 Family Member A1

Function

Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.

Biological Process

Cellular aldehyde metabolic process Source: UniProtKB
Choline catabolic process Source: Reactome
Glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway
Lysine catabolic process Source: Reactome
Sensory perception of sound Source: ProtInc

Cellular Location

Nucleus; Cytosol
Isoform 1: Mitochondrion

Involvement in disease

Pyridoxine-dependent epilepsy (PDE): Characterized by a combination of various seizure types. It usually occurs in the first hours of life and is unresponsive to standard anticonvulsants, responding only to immediate administration of pyridoxine hydrochloride.

Tan, M., Meng, J., Sun, X., Fu, X., & Wang, R. (2021). EPS8 supports pancreatic cancer growth by inhibiting BMI1 mediated proteasomal degradation of ALDH7A1. Experimental Cell Research, 112782.

Li, X., Fan, K., Liu, Y., Liu, Y., & Liu, P. F. (2021). Administration of a recombinant ALDH7A1 (rA7) indicates potential regulation of the metabolite and immunology pathways in Atlantic salmon infected with Aeromonas salmonicida. Journal of Fish Diseases, 44(7), 961-977.

Laciak, A. R., Korasick, D. A., Wyatt, J. W., Gates, K. S., & Tanner, J. J. (2020). Structural and biochemical consequences of pyridoxine‐dependent epilepsy mutations that target the aldehyde binding site of aldehyde dehydrogenase ALDH 7A1. The FEBS journal, 287(1), 173-189.

Faust, T. E. (2018). NOVEL MECHANISMS OF ALDEHYDE DEHYDROGENASE 7 FAMILY MEMBER A1 (ALDH7A1) IN THE BRAIN: ASTROCYTES, EXCITATORY-INHIBITORY BALANCE, AND BEHAVIORS (Doctoral dissertation, Johns Hopkins University).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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