Mouse Anti-ALDOC Monoclonal Antibody (1A1) (CBMAB-0935-YC)

Name: Mouse Anti-ALDOC Monoclonal Antibody (1A1)
SKU: CBMAB-0935-YC
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

1A1

Antibody Isotype

IgG1

Application

ICC, IF, FC, WB

Basic Information

Immunogen

The C-terminal 23 amino acids of human Aldolase C (KYEGSGEDGGAAAQSLYIANHAY).

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:2,000-1:5,000
IF(ICC)	1:1,000-1:2,000
FC	1 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% PBS, 50% glycerol

Preservative

5mM sodium azide

Concentration

1 mg/ml

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

Located in C-Terminal

Target

Introduction

Aldolase, fructose-bisphosphate C (ALDOC) is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. ALDOC is a member of the class I fructose-biphosphate aldolase gene family which is expressed specifically in the hippocampus and Purkinje cells of the brain.

Entrez Gene ID

Human	230
Mouse	11676
Rat	24191
Cattle	504584
Pig	100512013

UniProt ID

Human	P09972
Mouse	P05063
Rat	P09117
Cattle	A0A3S5ZPB0
Pig	A0A287B8Z2

Alternative Names

ALDC

Biological Process

Canonical glycolysis Source: Reactome
Epithelial cell differentiation Source: UniProtKB
Fructose 1,6-bisphosphate metabolic process Source: UniProtKB
Fructose metabolic process Source: ProtInc
Gluconeogenesis Source: Reactome
Glycolytic process Source: GO_Central
Neutrophil degranulation Source: Reactome

Cellular Location

Cytoskeleton; Cytosol; Extracellular exosome; Extracellular region; Ficolin-1-rich granule lumen; Secretory granule lumen; Tertiary granule lumen

More Infomation

References

Izraely, S., Ben‐Menachem, S., Sagi‐Assif, O., Meshel, T., Malka, S., Telerman, A., ... & Witz, I. P. (2021). The melanoma brain metastatic microenvironment: aldolase C partakes in shaping the malignant phenotype of melanoma cells–a case of inter‐tumor heterogeneity. Molecular Oncology, 15(5), 1376-1390.

Yuan, J., Xing, H., Li, Y., Song, Y., Zhang, N., Xie, M., ... & Yang, M. (2021). EPB41 suppresses the Wnt/β-catenin signaling in non-small cell lung cancer by sponging ALDOC. Cancer Letters, 499, 255-264.

Chang, Y. C., Tsai, H. F., Huang, S. P., Chen, C. L., Hsiao, M., & Tsai, W. C. (2019). Enrichment of aldolase C correlates with low non-mutated IDH1 expression and predicts a favorable prognosis in glioblastomas. Cancers, 11(9), 1238.

Pamidimukkala, N. V., Leonard, M. K., Snyder, D., Mccorkle, J. R., & Kaetzel, D. M. (2018). Metastasis suppressor NME1 directly activates transcription of the ALDOC gene in melanoma cells. Anticancer research, 38(11), 6059-6068.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Mouse Anti-ALDOC Monoclonal Antibody (4A9) (CAT#: CBMAB-0936-YC)

Mouse Anti-ALDOC Recombinant Antibody (E9) (CAT#: CBMAB-1067-CN)

Mouse Anti-ALDOC Recombinant Antibody (CF021) (CAT#: CBMAB-FT444LY)

Mouse Anti-ALDOC Recombinant Antibody (CBYC-A532) (CAT#: CBMAB-A2335-YC)

Mouse Anti-ALDOC Recombinant Antibody (2E11) (CAT#: CBMAB-1066-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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