Mouse Anti-ALDOC Recombinant Antibody (5H7A5) (CBMAB-A2332-YC)

Name: Mouse Anti-ALDOC Recombinant Antibody (5H7A5)
SKU: CBMAB-A2332-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

5H7A5

Application

WB, IHC, IF

Immunogen

Aldolase C fusion protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:5,000-1:50,000
IF(ICC)	1:50-1:400
IHC	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH7.3, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Aldolase, Fructose-Bisphosphate C

Introduction

ALDOC is a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-

Entrez Gene ID

230

UniProt ID

P09972

Alternative Names

Aldolase, Fructose-Bisphosphate C; Aldolase C, Fructose-Bisphosphate; Brain-Type Aldolase; EC 4.1.2.13; ALDC; Fructose-1,6-Biphosphate Triosephosphate Lyase; Fructose-Bisphosphate Aldolase C; Fructoaldolase C; Aldolase 3;

Biological Process

Canonical glycolysis Source: Reactome
Epithelial cell differentiation Source: UniProtKB
Fructose 1,6-bisphosphate metabolic process Source: UniProtKB
Fructose metabolic process Source: ProtInc
Gluconeogenesis Source: Reactome
Glycolytic process Source: GO_Central
Neutrophil degranulation Source: Reactome

Cellular Location

Cytoskeleton; Cytosol; Extracellular exosome; Extracellular region; Ficolin-1-rich granule lumen; Secretory granule lumen; Tertiary granule lumen

Izraely, S., Ben‐Menachem, S., Sagi‐Assif, O., Meshel, T., Malka, S., Telerman, A., ... & Witz, I. P. (2021). The melanoma brain metastatic microenvironment: aldolase C partakes in shaping the malignant phenotype of melanoma cells–a case of inter‐tumor heterogeneity. Molecular Oncology, 15(5), 1376-1390.

Yuan, J., Xing, H., Li, Y., Song, Y., Zhang, N., Xie, M., ... & Yang, M. (2021). EPB41 suppresses the Wnt/β-catenin signaling in non-small cell lung cancer by sponging ALDOC. Cancer Letters, 499, 255-264.

Chang, Y. C., Tsai, H. F., Huang, S. P., Chen, C. L., Hsiao, M., & Tsai, W. C. (2019). Enrichment of aldolase C correlates with low non-mutated IDH1 expression and predicts a favorable prognosis in glioblastomas. Cancers, 11(9), 1238.

Pamidimukkala, N. V., Leonard, M. K., Snyder, D., Mccorkle, J. R., & Kaetzel, D. M. (2018). Metastasis suppressor NME1 directly activates transcription of the ALDOC gene in melanoma cells. Anticancer research, 38(11), 6059-6068.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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