Mouse Anti-AMH Recombinant Antibody (CBFYM-0787) (CBMAB-M0931-FY)

Name: Mouse Anti-AMH Recombinant Antibody (CBFYM-0787)
SKU: CBMAB-M0931-FY
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-AMH Recombinant Antibody (CBFYM-0787) in ICC

Immunocytochemistry analysis of the isolated immature Sertoli cells (IMSC). ...View More

Chen, X., Zheng, Y., Li, X., Gao, Q., Feng, T., Zhang, P., ... & Zeng, W. (2020). Profiling of miRNAs in porcine Sertoli cells. Journal of Animal Science and Biotechnology, 11(1), 1-14.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-0787

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 46-345 mapping within an internal region of MIS of human origin.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:30-1:3,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Anti-Mullerian Hormone

Introduction

This gene encodes a secreted ligand of the TGF-beta superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome.

Entrez Gene ID

268

UniProt ID

P03971

Alternative Names

Anti-Mullerian Hormone; Muellerian-Inhibiting Substance; Anti-Muellerian Hormone; MIF; MIS; Mullerian Inhibiting Substance; Muellerian-Inhibiting Factor; Mullerian Inhibiting Factor

Function

This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.

Biological Process

Aging Source: Ensembl
BMP signaling pathway Source: Reactome
Cell-cell signaling Source: ProtInc
Gonadal mesoderm development Source: UniProtKB-KW
Mullerian duct regression Source: UniProtKB
Negative regulation of ovarian follicle development Source: Ensembl
Positive regulation of gene expression Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: Ensembl
Preantral ovarian follicle growth Source: Ensembl
Response to drug Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Sex determination Source: ProtInc
Sex differentiation Source: UniProtKB
Urogenital system development Source: GO_Central

Cellular Location

Secreted

Involvement in disease

Persistent Muellerian duct syndrome 1 (PMDS1): A form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.

Moolhuijsen, L. M., & Visser, J. A. (2020). Anti-Müllerian hormone and ovarian reserve: Update on assessing ovarian function. The Journal of Clinical Endocrinology & Metabolism, 105(11), 3361-3373.

Hoyos, L. R., Visser, J. A., McLuskey, A., Chazenbalk, G. D., Grogan, T. R., & Dumesic, D. A. (2020). Loss of anti-Müllerian hormone (AMH) immunoactivity due to a homozygous AMH gene variant rs10417628 in a woman with classical polycystic ovary syndrome (PCOS). Human Reproduction, 35(10), 2294-2302.

Huang, X., Xu, X., Dai, Y., Cheng, Z., Zheng, X., & Huo, X. (2020). Association of prenatal exposure to PAHs with anti-Müllerian hormone (AMH) levels and birth outcomes of newborns. Science of the Total Environment, 723, 138009.

Zhang, Z., Zhu, B., Chen, W., & Ge, W. (2020). Anti-Müllerian hormone (Amh/amh) plays dual roles in maintaining gonadal homeostasis and gametogenesis in zebrafish. Molecular and Cellular Endocrinology, 110963.

Xu, H. Y., Zhang, H. X., Xiao, Z., Qiao, J., & Li, R. (2019). Regulation of anti-Müllerian hormone (AMH) in males and the associations of serum AMH with the disorders of male fertility. Asian journal of andrology, 21(2), 109.

Yan, Y. L., Batzel, P., Titus, T., Sydes, J., Desvignes, T., BreMiller, R., ... & Postlethwait, J. H. (2019). A hormone that lost its receptor: anti-Müllerian hormone (AMH) in zebrafish gonad development and sex determination. Genetics, 213(2), 529-553.

Abbara, A., Eng, P. C., Phylactou, M., Clarke, S. A., Hunjan, T., Roberts, R., ... & Dhillo, W. S. (2019). Anti-Müllerian hormone (AMH) in the diagnosis of menstrual disturbance due to polycystic ovarian syndrome. Frontiers in endocrinology, 10, 656.

Sova, H., Unkila-Kallio, L., Tiitinen, A., Hippeläinen, M., Perheentupa, A., Tinkanen, H., ... & Morin-Papunen, L. (2019). Hormone profiling, including anti-Müllerian hormone (AMH), for the diagnosis of polycystic ovary syndrome (PCOS) and characterization of PCOS phenotypes. Gynecological Endocrinology, 35(7), 595-600.

Stracquadanio, M., Ciotta, L., & Palumbo, M. A. (2018). Relationship between serum anti-Mullerian hormone and intrafollicular AMH levels in PCOS women. Gynecological Endocrinology, 34(3), 223-228.

Kruszyńska, A., & Słowińska-Srzednicka, J. (2017). Anti-Müllerian hormone (AMH) as a good predictor of time of menopause. Przeglad menopauzalny= Menopause review, 16(2), 47.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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