AMH

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016]
Full Name
Anti-Mullerian Hormone
Function
This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.
Biological Process
Aging Source: Ensembl
BMP signaling pathway Source: Reactome
Cell-cell signaling Source: ProtInc
Gonadal mesoderm development Source: UniProtKB-KW
Mullerian duct regression Source: UniProtKB
Negative regulation of ovarian follicle development Source: Ensembl
Positive regulation of gene expression Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: Ensembl
Preantral ovarian follicle growth Source: Ensembl
Response to drug Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Sex determination Source: ProtInc
Sex differentiation Source: UniProtKB
Urogenital system development Source: GO_Central
Cellular Location
Secreted
Involvement in disease
Persistent Muellerian duct syndrome 1 (PMDS1): A form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
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Anti-AMH antibodies

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Mouse Anti-AMH Recombinant Antibody (5/6) (CBMAB-A2527-YC)

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Target: AMH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse, Sheep
Clone: 5/6
Application*: WB, P
Datasheet SDS

Rabbit Anti-AMH Recombinant Antibody (CBFYM-0853) (CBMAB-M1000-FY)

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Target: AMH
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-0853
Application*: E
Datasheet SDS

Rat Anti-AMH Recombinant Antibody (CBFYM-0849) (CBMAB-M0996-FY)

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Target: AMH
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYM-0849
Application*: WB
Datasheet SDS

Mouse Anti-AMH Recombinant Antibody (CBFYM-0847) (CBMAB-M0994-FY)

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Target: AMH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0847
Application*: P
Datasheet SDS

Rabbit Anti-AMH Recombinant Antibody (CBFYM-0846) (CBMAB-M0993-FY)

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Target: AMH
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-0846
Application*: E
Datasheet SDS

Mouse Anti-AMH Recombinant Antibody (CBFYM-0787) (CBMAB-M0931-FY)

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Target: AMH
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0787
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-AMH Recombinant Antibody (CBYC-A558) (CBMAB-A2531-YC)

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Target: AMH
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYC-A558
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-AMH Recombinant Antibody (CBYC-A557) (CBMAB-A2530-YC)

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Target: AMH
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYC-A557
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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