Mouse Anti-ANGPT2 Recombinant Antibody (CBYC-A585) (CBMAB-A2679-YC)

Name: Mouse Anti-ANGPT2 Recombinant Antibody (CBYC-A585)
SKU: CBMAB-A2679-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYC-A585

Application

ELISA

Immunogen

Recombinant Human Angiopoietin-2 Protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Angiopoietin 2

Introduction

ANGPT2 is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis.

Entrez Gene ID

Human	285
Mouse	11601
Rat	89805

UniProt ID

Human	O15123
Mouse	O35608
Rat	O35462

Alternative Names

Angiopoietin 2; ANG-2; Angiopoietin-2B; Angiopoietin-2a; Angiopoietin-2; Tie2-Ligand; AGPT2; ANG2;

Function

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

Biological Process

Angiogenesis Source: GO_Central
Animal organ regeneration Source: Ensembl
Cellular response to growth factor stimulus Source: Ensembl
Gene expression Source: MGI
Germ cell development Source: Ensembl
Glomerulus vasculature development Source: UniProtKB
Leukocyte migration Source: Reactome
Maternal process involved in female pregnancy Source: Ensembl
Negative regulation of angiogenesis Source: Ensembl
Negative regulation of blood vessel endothelial cell migration Source: UniProtKB
Negative regulation of cell-substrate adhesion Source: Ensembl
Negative regulation of positive chemotaxis Source: UniProtKB
Positive regulation of angiogenesis Source: Ensembl
Response to activity Source: Ensembl
Response to glucose Source: Ensembl
Response to hypoxia Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Response to radiation Source: Ensembl
Signal transduction Source: ProtInc
Tie signaling pathway Source: UniProtKB

Cellular Location

Secreted

Kamiyama, M., & Augustin, H. G. (2021). Alternatively Spliced Form of Angiopoietin-2 as a New Vascular Rheostat. Cancer Research, 81(1), 35-37.

Aarsetøy, R., Ueland, T., Aukrust, P., Michelsen, A. E., de la Fuente, R. L., Pönitz, V., ... & Nilsen, D. W. (2021). Angiopoietin‐2 and angiopoietin‐like 4 protein provide prognostic information in patients with suspected acute coronary syndrome. Journal of internal medicine.

Hultstrom, M., Fromell, K., Larsson, A., Quaggin, S. E., Betsholtz, C., Frithiof, R., ... & Jeansson, M. (2021). Elevated Angiopoietin-2 inhibits thrombomodulin-mediated anticoagulation in critically ill COVID-19 patients. medRxiv.

Xie, J. Y., Wei, J. X., Lv, L. H., Han, Q. F., Yang, W. B., Li, G. L., ... & Min, J. (2020). Angiopoietin-2 induces angiogenesis via exosomes in human hepatocellular carcinoma. Cell Communication and Signaling, 18(1), 1-13.

Pari, A. A. A., Singhal, M., Hübers, C., Mogler, C., Schieb, B., Gampp, A., ... & Felcht, M. (2020). Tumor Cell–Derived Angiopoietin-2 Promotes Metastasis in Melanoma. Cancer research, 80(12), 2586-2598.

Crist, A. M., Zhou, X., Garai, J., Lee, A. R., Thoele, J., Ullmer, C., ... & Meadows, S. M. (2019). Angiopoietin-2 inhibition rescues arteriovenous malformation in a Smad4 hereditary hemorrhagic telangiectasia mouse model. Circulation, 139(17), 2049-2063.

Schlosser, K., Taha, M., Deng, Y., McIntyre, L. A., Mei, S. H., & Stewart, D. J. (2018). High circulating angiopoietin-2 levels exacerbate pulmonary inflammation but not vascular leak or mortality in endotoxin-induced lung injury in mice. Thorax, 73(3), 248-261.

Souma, T., Thomson, B. R., Heinen, S., Carota, I. A., Yamaguchi, S., Onay, T., ... & Quaggin, S. E. (2018). Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP. Proceedings of the National Academy of Sciences, 115(6), 1298-1303.

Reilly, J. P., Wang, F., Jones, T. K., Palakshappa, J. A., Anderson, B. J., Shashaty, M. G., ... & Meyer, N. J. (2018). Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive care medicine, 44(11), 1849-1858.

Wu, X., Giobbie-Hurder, A., Liao, X., Connelly, C., Connolly, E. M., Li, J., ... & Hodi, F. S. (2017). Angiopoietin-2 as a biomarker and target for immune checkpoint therapy. Cancer immunology research, 5(1), 17-28.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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