ANGPT2

The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
Angiopoietin 2
Function
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Biological Process
Angiogenesis Source: GO_Central
Animal organ regeneration Source: Ensembl
Cellular response to growth factor stimulus Source: Ensembl
Gene expression Source: MGI
Germ cell development Source: Ensembl
Glomerulus vasculature development Source: UniProtKB
Leukocyte migration Source: Reactome
Maternal process involved in female pregnancy Source: Ensembl
Negative regulation of angiogenesis Source: Ensembl
Negative regulation of blood vessel endothelial cell migration Source: UniProtKB
Negative regulation of cell-substrate adhesion Source: Ensembl
Negative regulation of positive chemotaxis Source: UniProtKB
Positive regulation of angiogenesis Source: Ensembl
Response to activity Source: Ensembl
Response to glucose Source: Ensembl
Response to hypoxia Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Response to radiation Source: Ensembl
Signal transduction Source: ProtInc
Tie signaling pathway Source: UniProtKB
Cellular Location
Secreted
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Anti-ANGPT2 antibodies

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Mouse Anti-ANGPT2 Recombinant Antibody (CBYC-A587) (CBMAB-A2681-YC)

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Target: ANGPT2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYC-A587
Application*: WB, IH, IC, IF
Datasheet SDS

Mouse Anti-ANGPT2 Recombinant Antibody (CBYC-A586) (CBMAB-A2680-YC)

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Target: ANGPT2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYC-A586
Application*: WB, IH, IC, IF, P
Datasheet SDS

Mouse Anti-ANGPT2 Recombinant Antibody (CBYC-A585) (CBMAB-A2679-YC)

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Target: ANGPT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-A585
Application*: E
Datasheet SDS

Mouse Anti-ANGPT2 Recombinant Antibody (Angy-2-1) (CBMAB-A2676-YC)

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Target: ANGPT2
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human, Mouse
Clone: Angy-2-1
Application*: E, B, IC
Functional Assay
Datasheet SDS

Human Anti-ANGPT2 Recombinant Antibody (Angy-1-4) (CBMAB-A2675-YC)

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Target: ANGPT2
Host: Human
Antibody Isotype: IgG2, λ
Specificity: Human
Clone: Angy-1-4
Application*: E
Datasheet SDS

Mouse Anti-ANGPT2 Recombinant Antibody (1F29) (CBMAB-A2672-YC)

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Target: ANGPT2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human, Chicken
Clone: 1F29
Application*: WB, IH, IC, IF
Datasheet SDS

Rabbit Anti-ANGPT2 Recombinant Antibody (A2669) (CBMAB-A2669-YC)

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Target: ANGPT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: A2669
Application*: WB, IC, IF, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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