ANGPT2
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
Angiopoietin 2
Function
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Biological Process
Angiogenesis Source: GO_Central
Animal organ regeneration Source: Ensembl
Cellular response to growth factor stimulus Source: Ensembl
Gene expression Source: MGI
Germ cell development Source: Ensembl
Glomerulus vasculature development Source: UniProtKB
Leukocyte migration Source: Reactome
Maternal process involved in female pregnancy Source: Ensembl
Negative regulation of angiogenesis Source: Ensembl
Negative regulation of blood vessel endothelial cell migration Source: UniProtKB
Negative regulation of cell-substrate adhesion Source: Ensembl
Negative regulation of positive chemotaxis Source: UniProtKB
Positive regulation of angiogenesis Source: Ensembl
Response to activity Source: Ensembl
Response to glucose Source: Ensembl
Response to hypoxia Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Response to radiation Source: Ensembl
Signal transduction Source: ProtInc
Tie signaling pathway Source: UniProtKB
Animal organ regeneration Source: Ensembl
Cellular response to growth factor stimulus Source: Ensembl
Gene expression Source: MGI
Germ cell development Source: Ensembl
Glomerulus vasculature development Source: UniProtKB
Leukocyte migration Source: Reactome
Maternal process involved in female pregnancy Source: Ensembl
Negative regulation of angiogenesis Source: Ensembl
Negative regulation of blood vessel endothelial cell migration Source: UniProtKB
Negative regulation of cell-substrate adhesion Source: Ensembl
Negative regulation of positive chemotaxis Source: UniProtKB
Positive regulation of angiogenesis Source: Ensembl
Response to activity Source: Ensembl
Response to glucose Source: Ensembl
Response to hypoxia Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Response to radiation Source: Ensembl
Signal transduction Source: ProtInc
Tie signaling pathway Source: UniProtKB
Cellular Location
Secreted
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Anti-ANGPT2 antibodies
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CompareTarget: Angpt2
Sensitivity: 0.022 pg/mL
Detection Range: 0.05-20 pg/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: ANGPT2
Sensitivity: 0.242 ng/mL
Detection Range: 0.5-100 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Pig
Assay Type: Sandwich
Reactivity: Pig
Target: ANGPT2
Sensitivity: 0.0052 ng/mL
Detection Range: 0.01-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Cattle
Assay Type: Sandwich
Reactivity: Cattle
Target: ANGPT2
Sensitivity: 0.013 ng/mL
Detection Range: 0.022-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Dog
Assay Type: Sandwich
Reactivity: Dog
Target: ANGPT2
Sensitivity: 0.0025 ng/mL
Detection Range: 0.005-1 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Angpt2
Sensitivity: 0.0092 ng/mL
Detection Range: 0.02-6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: ANGPT2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 275-496
Tag: His Tag
Target: ANGPT2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-248 and 275-496
Tag: Fc Tag
Target: ANGPT2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 19-496
Tag: Fc Tag
Target: ANGPT2
Expressed Host: CHO Stable Cells
Sequence: Amino Acid: 1-496
Tag: His Tag
Target: ANGPT2
Expressed Host: CHO Stable Cells
Sequence: Amino Acid: 1-496
Tag: His Tag
Target: ANGPT2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 275-496
Tag: His Tag
Target: ANGPT2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-496
Tag: His Tag
Target: ANGPT2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 275-496
Tag: His & AVI Tag
Target: ANGPT2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-496
Tag: hFc Tag
Target: ANGPT2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-495
Tag: His Tag
Target: ANGPT2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 274-495
Tag: His Tag
Target: ANGPT2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 274-495
Tag: hFc Tag
Target: ANGPT2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 274-495
Tag: His Tag
Target: ANGPT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 1F10
Application*: E, WB, IH
Target: ANGPT2
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 5A9
Application*: E
Target: ANGPT2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYC-A587
Application*: WB, IH, IC, IF
Target: ANGPT2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYC-A586
Application*: WB, IH, IC, IF, P
Target: ANGPT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-A585
Application*: E
Target: ANGPT2
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human, Mouse
Clone: Angy-2-1
Application*: E, B, IC
Target: ANGPT2
Host: Human
Antibody Isotype: IgG2, λ
Specificity: Human
Clone: Angy-1-4
Application*: E
Target: ANGPT2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human, Chicken
Clone: 1F29
Application*: WB, IH, IC, IF
Target: ANGPT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: A2669
Application*: WB, IC, IF, IP
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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