Sign in or Register   Sign in or Register
  |  

Human Anti-ANGPT2 Recombinant Antibody (Angy-1-4) (CBMAB-A2675-YC)

Provided herein is a Human monoclonal antibody against Human Angiopoietin 2. The antibody can be used for immunoassay techniques, such as ELISA.
See all ANGPT2 antibodies

Summary

Host Animal
Human
Specificity
Human
Clone
Angy-1-4
Antibody Isotype
IgG2, λ
Application
ELISA

Basic Information

Immunogen
Recombinant protein corresponding to human Angiopoietin-2 expressed in CHO cells
Host Species
Human
Specificity
Human
Antibody Isotype
IgG2, λ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 10% glycerol
Preservative
None
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Angiopoietin 2
Introduction
ANGPT2 is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis.
Entrez Gene ID
285
UniProt ID
O15123
Alternative Names
Angiopoietin 2; ANG-2; Angiopoietin-2B; Angiopoietin-2a; Angiopoietin-2; Tie2-Ligand; AGPT2; ANG2;
Function
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Biological Process
Angiogenesis Source: GO_Central
Animal organ regeneration Source: Ensembl
Cellular response to growth factor stimulus Source: Ensembl
Gene expression Source: MGI
Germ cell development Source: Ensembl
Glomerulus vasculature development Source: UniProtKB
Leukocyte migration Source: Reactome
Maternal process involved in female pregnancy Source: Ensembl
Negative regulation of angiogenesis Source: Ensembl
Negative regulation of blood vessel endothelial cell migration Source: UniProtKB
Negative regulation of cell-substrate adhesion Source: Ensembl
Negative regulation of positive chemotaxis Source: UniProtKB
Positive regulation of angiogenesis Source: Ensembl
Response to activity Source: Ensembl
Response to glucose Source: Ensembl
Response to hypoxia Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Response to radiation Source: Ensembl
Signal transduction Source: ProtInc
Tie signaling pathway Source: UniProtKB
Cellular Location
Secreted

Kamiyama, M., & Augustin, H. G. (2021). Alternatively Spliced Form of Angiopoietin-2 as a New Vascular Rheostat. Cancer Research, 81(1), 35-37.

Aarsetøy, R., Ueland, T., Aukrust, P., Michelsen, A. E., de la Fuente, R. L., Pönitz, V., ... & Nilsen, D. W. (2021). Angiopoietin‐2 and angiopoietin‐like 4 protein provide prognostic information in patients with suspected acute coronary syndrome. Journal of internal medicine.

Hultstrom, M., Fromell, K., Larsson, A., Quaggin, S. E., Betsholtz, C., Frithiof, R., ... & Jeansson, M. (2021). Elevated Angiopoietin-2 inhibits thrombomodulin-mediated anticoagulation in critically ill COVID-19 patients. medRxiv.

Xie, J. Y., Wei, J. X., Lv, L. H., Han, Q. F., Yang, W. B., Li, G. L., ... & Min, J. (2020). Angiopoietin-2 induces angiogenesis via exosomes in human hepatocellular carcinoma. Cell Communication and Signaling, 18(1), 1-13.

Pari, A. A. A., Singhal, M., Hübers, C., Mogler, C., Schieb, B., Gampp, A., ... & Felcht, M. (2020). Tumor Cell–Derived Angiopoietin-2 Promotes Metastasis in Melanoma. Cancer research, 80(12), 2586-2598.

Crist, A. M., Zhou, X., Garai, J., Lee, A. R., Thoele, J., Ullmer, C., ... & Meadows, S. M. (2019). Angiopoietin-2 inhibition rescues arteriovenous malformation in a Smad4 hereditary hemorrhagic telangiectasia mouse model. Circulation, 139(17), 2049-2063.

Schlosser, K., Taha, M., Deng, Y., McIntyre, L. A., Mei, S. H., & Stewart, D. J. (2018). High circulating angiopoietin-2 levels exacerbate pulmonary inflammation but not vascular leak or mortality in endotoxin-induced lung injury in mice. Thorax, 73(3), 248-261.

Souma, T., Thomson, B. R., Heinen, S., Carota, I. A., Yamaguchi, S., Onay, T., ... & Quaggin, S. E. (2018). Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP. Proceedings of the National Academy of Sciences, 115(6), 1298-1303.

Reilly, J. P., Wang, F., Jones, T. K., Palakshappa, J. A., Anderson, B. J., Shashaty, M. G., ... & Meyer, N. J. (2018). Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive care medicine, 44(11), 1849-1858.

Wu, X., Giobbie-Hurder, A., Liao, X., Connelly, C., Connolly, E. M., Li, J., ... & Hodi, F. S. (2017). Angiopoietin-2 as a biomarker and target for immune checkpoint therapy. Cancer immunology research, 5(1), 17-28.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Human Anti-ANGPT2 Recombinant Antibody (Angy-1-4)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare