Pig ANGPT2 ELISA Kit (V2LY-0626-LY649)

Name: Pig ANGPT2 ELISA Kit
SKU: V2LY-0626-LY649
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.242 ng/mL

Detection Range

0.5-100 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Pig

Assay Type

Sandwich

Reactivity

Pig

Assay Time

1.5 h

Molecule Mass

56.9 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Angiopoietin 2

Function

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

Biological Process

Angiogenesis Source: GO_Central
Animal organ regeneration Source: Ensembl
Cellular response to growth factor stimulus Source: Ensembl
Gene expression Source: MGI
Germ cell development Source: Ensembl
Glomerulus vasculature development Source: UniProtKB
Leukocyte migration Source: Reactome
Maternal process involved in female pregnancy Source: Ensembl
Negative regulation of angiogenesis Source: Ensembl
Negative regulation of blood vessel endothelial cell migration Source: UniProtKB
Negative regulation of cell-substrate adhesion Source: Ensembl
Negative regulation of positive chemotaxis Source: UniProtKB
Positive regulation of angiogenesis Source: Ensembl
Response to activity Source: Ensembl
Response to glucose Source: Ensembl
Response to hypoxia Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Response to radiation Source: Ensembl
Signal transduction Source: ProtInc
Tie signaling pathway Source: UniProtKB

Cellular Location

Secreted

Kamiyama, M., & Augustin, H. G. (2021). Alternatively Spliced Form of Angiopoietin-2 as a New Vascular Rheostat. Cancer Research, 81(1), 35-37.

Aarsetøy, R., Ueland, T., Aukrust, P., Michelsen, A. E., de la Fuente, R. L., Pönitz, V., ... & Nilsen, D. W. (2021). Angiopoietin‐2 and angiopoietin‐like 4 protein provide prognostic information in patients with suspected acute coronary syndrome. Journal of internal medicine.

Hultstrom, M., Fromell, K., Larsson, A., Quaggin, S. E., Betsholtz, C., Frithiof, R., ... & Jeansson, M. (2021). Elevated Angiopoietin-2 inhibits thrombomodulin-mediated anticoagulation in critically ill COVID-19 patients. medRxiv.

Xie, J. Y., Wei, J. X., Lv, L. H., Han, Q. F., Yang, W. B., Li, G. L., ... & Min, J. (2020). Angiopoietin-2 induces angiogenesis via exosomes in human hepatocellular carcinoma. Cell Communication and Signaling, 18(1), 1-13.

Pari, A. A. A., Singhal, M., Hübers, C., Mogler, C., Schieb, B., Gampp, A., ... & Felcht, M. (2020). Tumor Cell–Derived Angiopoietin-2 Promotes Metastasis in Melanoma. Cancer research, 80(12), 2586-2598.

Crist, A. M., Zhou, X., Garai, J., Lee, A. R., Thoele, J., Ullmer, C., ... & Meadows, S. M. (2019). Angiopoietin-2 inhibition rescues arteriovenous malformation in a Smad4 hereditary hemorrhagic telangiectasia mouse model. Circulation, 139(17), 2049-2063.

Schlosser, K., Taha, M., Deng, Y., McIntyre, L. A., Mei, S. H., & Stewart, D. J. (2018). High circulating angiopoietin-2 levels exacerbate pulmonary inflammation but not vascular leak or mortality in endotoxin-induced lung injury in mice. Thorax, 73(3), 248-261.

Souma, T., Thomson, B. R., Heinen, S., Carota, I. A., Yamaguchi, S., Onay, T., ... & Quaggin, S. E. (2018). Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP. Proceedings of the National Academy of Sciences, 115(6), 1298-1303.

Reilly, J. P., Wang, F., Jones, T. K., Palakshappa, J. A., Anderson, B. J., Shashaty, M. G., ... & Meyer, N. J. (2018). Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive care medicine, 44(11), 1849-1858.

Wu, X., Giobbie-Hurder, A., Liao, X., Connelly, C., Connolly, E. M., Li, J., ... & Hodi, F. S. (2017). Angiopoietin-2 as a biomarker and target for immune checkpoint therapy. Cancer immunology research, 5(1), 17-28.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Angpt2 ELISA Kit (CAT#: V2LY-0626-LY1071)

Human ANGPT2 ELISA Kit (CAT#: V2LY-0626-LY1495)

Dog ANGPT2 ELISA Kit (CAT#: V2LY-0626-LY217)

Cattle ANGPT2 ELISA Kit (CAT#: V2LY-0626-LY230)

Mouse Angpt2 ELISA Kit (CAT#: V2LY-0626-LY742)

Canine Recombinant ANGPT2 protein, His Tag (CAT#: V2LY-0526-LY1201)

Cynomolgus, Rhesus Recombinant ANGPT2 protein, hFc Tag (CAT#: V2LY-0526-LY1674)

Cynomolgus, Rhesus Recombinant ANGPT2 protein, His Tag (CAT#: V2LY-0526-LY1675)

Cynomolgus, Rhesus Recombinant ANGPT2 protein, His Tag-1 (CAT#: V2LY-0526-LY1676)

Human Recombinant ANGPT2 protein, hFc Tag (CAT#: V2LY-0526-LY2105)

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Mouse Angpt2 ELISA Kit (CAT#: V2LY-0626-LY742)

Cynomolgus, Rhesus Recombinant ANGPT2 protein, His Tag (CAT#: V2LY-0526-LY1675)

Mouse Recombinant ANGPT2 protein, His Tag (CAT#: V2LY-0526-LY7806)

Mouse Anti-ANGPT2 Recombinant Antibody (Angy-2-1) (CAT#: CBMAB-A2676-YC)

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Human ANGPT2 ELISA Kit (CAT#: V2LY-0626-LY1495)

Human Recombinant ANGPT2 protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY2110)

Cattle ANGPT2 ELISA Kit (CAT#: V2LY-0626-LY230)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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