Rat Anti-ANGPT4 Recombinant Antibody (2H34) (CBMAB-A2692-YC)

Name: Rat Anti-ANGPT4 Recombinant Antibody (2H34)
SKU: CBMAB-A2692-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

2H34

Application

WB, IHC-P

Immunogen

Mouse recombinant Angiopoietin-3

Host Species

Rat

Specificity

Mouse

Antibody Isotype

IgG2

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS

Preservative

None

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

angiopoietin 4

Introduction

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis

Entrez Gene ID

11602

UniProt ID

Q9WVH6

Alternative Names

Angiopoietin 4; ANG3; ANG4; Angiopoietin-4; Angiopoietin-3; ANG-3; ANG-4;

Function

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.

Biological Process

Angiogenesis Source: GO_Central
Cellular response to hypoxia Source: UniProtKB
Leukocyte migration Source: Reactome
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of blood vessel endothelial cell migration Source: UniProtKB
Notch signaling pathway Source: Ensembl
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of blood vessel endothelial cell migration Source: UniProtKB
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Signal transduction Source: GO_Central

Cellular Location

Secreted

Haghshenas, R. (2020). The Effect of Rope Training on the Plasma Level of Angiopoietin-4, Interleukin-6, and Lipid Profile of Overweight Boys. Iranian Journal of Endocrinology and Metabolism, 22(2), 162-168.

Jeong, S. Y., Kang, M. L., Park, J. W., & Im, G. I. (2020). Dual functional nanoparticles containing SOX duo and ANGPT4 shRNA for osteoarthritis treatment. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 108(1), 234-242.

Elamaa, H., Kihlström, M., Kapiainen, E., Kaakinen, M., Miinalainen, I., Ragauskas, S., ... & Eklund, L. (2018). Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retina. Elife, 7, e37776.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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