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Mouse Anti-ANGPT4 Recombinant Antibody (CBYC-A592) (CBMAB-A2693-YC)

Provided herein is a Mouse monoclonal antibody against Human Angiopoietin 4. The antibody can be used for immunoassay techniques, such as WB, ICC, IHC-P, IHC-Fr, ELISA.
See all ANGPT4 antibodies
Published Data
Mouse Anti-ANGPT4 Recombinant Antibody (CBYC-A592) in WB
Original blot images of all quantifications from Western blotting. ...View More
Fu, Y., Mei, Q., Yin, N., Huang, Z., Li, B., Luo, S., ... & Zeng, Y. (2022). Paneth cells protect against acute pancreatitis Via modulating gut microbiota dysbiosis. Msystems, 7(3), e01507-21.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYC-A592
Antibody Isotype
IgM, κ
Application
WB, IHC, ICC, IF

Basic Information

Immunogen
Amino acids 5-41 near the N-terminus of Ang-4 of mouse origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
angiopoietin 4
Introduction
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis
Entrez Gene ID
51378
UniProt ID
Q9Y264
Alternative Names
ANG3; ANG4
Function
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
Biological Process
Angiogenesis Source: GO_Central
Cellular response to hypoxia Source: UniProtKB
Leukocyte migration Source: Reactome
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of blood vessel endothelial cell migration Source: UniProtKB
Notch signaling pathway Source: Ensembl
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of blood vessel endothelial cell migration Source: UniProtKB
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Signal transduction Source: GO_Central
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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