ANGPT4

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq]
Full Name
angiopoietin 4
Function
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
Biological Process
Angiogenesis Source: GO_Central
Cellular response to hypoxia Source: UniProtKB
Leukocyte migration Source: Reactome
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of blood vessel endothelial cell migration Source: UniProtKB
Notch signaling pathway Source: Ensembl
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of blood vessel endothelial cell migration Source: UniProtKB
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Signal transduction Source: GO_Central
Cellular Location
Secreted
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Anti-ANGPT4 antibodies

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Mouse Anti-ANGPT4 Recombinant Antibody (CBYC-A592) (CBMAB-A2693-YC)

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Target: ANGPT4
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat
Clone: CBYC-A592
Application*: WB, IH, IC, IF
Datasheet SDS

Rat Anti-ANGPT4 Recombinant Antibody (2H34) (CBMAB-A2692-YC)

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Target: ANGPT4
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 2H34
Application*: WB, P
Datasheet SDS

Mouse Anti-ANGPT4 Recombinant Antibody (1B7) (CBMAB-A2691-YC)

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Target: ANGPT4
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1B7
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-ANGPT4 Recombinant Antibody (11M11) (CBMAB-A2687-YC)

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Target: ANGPT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11M11
Application*: WB, IH
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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