ANGPT4

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq]

angiopoietin 4

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.

Angiogenesis Source: GO_Central
Cellular response to hypoxia Source: UniProtKB
Leukocyte migration Source: Reactome
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of blood vessel endothelial cell migration Source: UniProtKB
Notch signaling pathway Source: Ensembl
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of blood vessel endothelial cell migration Source: UniProtKB
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Signal transduction Source: GO_Central

Secreted