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ANGPT4

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq]

Full Name

angiopoietin 4

Function

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.

Biological Process

Angiogenesis Source: GO_Central
Cellular response to hypoxia Source: UniProtKB
Leukocyte migration Source: Reactome
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of blood vessel endothelial cell migration Source: UniProtKB
Notch signaling pathway Source: Ensembl
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of blood vessel endothelial cell migration Source: UniProtKB
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Signal transduction Source: GO_Central

Cellular Location

Secreted

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Anti-ANGPT4 antibodies

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Human Recombinant ANGPT4 protein, His Tag (V2LY-0526-LY2114)

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Target: ANGPT4

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 282-503

Tag: His Tag

Human Recombinant ANGPT4 protein, hFc Tag (V2LY-0526-LY2113)

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Target: ANGPT4

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 282-503

Tag: hFc Tag

Mouse Anti-ANGPT4 Recombinant Antibody (CBYC-A592) (CBMAB-A2693-YC)

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Target: ANGPT4

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human, Mouse, Rat

Clone: CBYC-A592

Application*: WB, IH, IC, IF

Rat Anti-ANGPT4 Recombinant Antibody (2H34) (CBMAB-A2692-YC)

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Target: ANGPT4

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: 2H34

Application*: WB, P

Mouse Anti-ANGPT4 Recombinant Antibody (1B7) (CBMAB-A2691-YC)

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Target: ANGPT4

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1B7

Application*: E, IH, WB

Mouse Anti-ANGPT4 Recombinant Antibody (11M11) (CBMAB-A2687-YC)

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Target: ANGPT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 11M11

Application*: WB, IH

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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