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Mouse Anti-ANKRD17 Recombinant Antibody (1D12) (CBMAB-A2775-YC)

Provided herein is a Mouse monoclonal antibody against Human Ankyrin Repeat Domain 17. The antibody can be used for immunoassay techniques, such as ELISA, ICC, IF, WB.
See all ANKRD17 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D12
Antibody Isotype
IgG1, κ
Application
ELISA, ICC, IF, WB

Basic Information

Immunogen
ANKRD17 (NP_115593, 2501-2603 aa) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)10 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ankyrin repeat domain 17
Introduction
ANKRD17 belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export si
Entrez Gene ID
26057
UniProt ID
O75179
Alternative Names
Ankyrin Repeat Domain 17; Serologically Defined Breast Cancer Antigen NY-BR-16; Gene Trap Ankyrin Repeat Protein; GTAR; Ankyrin Repeat Domain-Containing Protein 17; NY-BR-16; KIAA0697; MASK2;
Function
Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).
Biological Process
Blood vessel maturation Source: Ensembl
Defense response to bacterium Source: UniProtKB
Innate immune response Source: UniProtKB
Negative regulation of smooth muscle cell differentiation Source: Ensembl
Positive regulation of cell cycle Source: UniProtKB
Positive regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Positive regulation of MDA-5 signaling pathway Source: UniProtKB
Positive regulation of RIG-I signaling pathway Source: UniProtKB
Regulation of DNA replication Source: UniProtKB
Viral process Source: UniProtKB-KW
Cellular Location
Cytoplasm; Nucleus. Detected around the nucleolus. Localized on chromatin in a cell cycle-dependent manner.
PTM
Phosphorylated by CDK2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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