ANKRD17

This gene encodes a protein with ankyrin repeats, which are associated with protein-protein interactions. Studies in mice suggest that this protein is involved in liver development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

ankyrin repeat domain 17

Function

Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).

Biological Process

Blood vessel maturation Source: Ensembl
Defense response to bacterium Source: UniProtKB
Innate immune response Source: UniProtKB
Negative regulation of smooth muscle cell differentiation Source: Ensembl
Positive regulation of cell cycle Source: UniProtKB
Positive regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Positive regulation of MDA-5 signaling pathway Source: UniProtKB
Positive regulation of RIG-I signaling pathway Source: UniProtKB
Regulation of DNA replication Source: UniProtKB
Viral process Source: UniProtKB-KW

Cellular Location

Cytoplasm; Nucleus. Detected around the nucleolus. Localized on chromatin in a cell cycle-dependent manner.

PTM

Phosphorylated by CDK2.