Mouse Anti-ANKRD17 Recombinant Antibody (1D8) (CBMAB-A2776-YC)

Name: Mouse Anti-ANKRD17 Recombinant Antibody (1D8)
SKU: CBMAB-A2776-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1D8

Application

ELISA

Immunogen

ANKRD17 (NP_115593, 2501 a.a. ~ 2603 a.a) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ankyrin repeat domain 17

Introduction

ANKRD17 belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export si

Entrez Gene ID

26057

UniProt ID

O75179

Alternative Names

Ankyrin Repeat Domain 17; Serologically Defined Breast Cancer Antigen NY-BR-16; Gene Trap Ankyrin Repeat Protein; GTAR; Ankyrin Repeat Domain-Containing Protein 17; NY-BR-16; KIAA0697; MASK2;

Function

Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).

Biological Process

Blood vessel maturation Source: Ensembl
Defense response to bacterium Source: UniProtKB
Innate immune response Source: UniProtKB
Negative regulation of smooth muscle cell differentiation Source: Ensembl
Positive regulation of cell cycle Source: UniProtKB
Positive regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Positive regulation of MDA-5 signaling pathway Source: UniProtKB
Positive regulation of RIG-I signaling pathway Source: UniProtKB
Regulation of DNA replication Source: UniProtKB
Viral process Source: UniProtKB-KW

Cellular Location

Cytoplasm; Nucleus. Detected around the nucleolus. Localized on chromatin in a cell cycle-dependent manner.

PTM

Phosphorylated by CDK2.

Li, M., Qi, W., Chang, Q., Chen, R., Zhen, D., Liao, M., ... & Deng, Y. (2021). Influenza A virus protein PA‐X suppresses host Ankrd17‐mediated immune responses. Microbiology and Immunology, 65(1), 48-59.

Chopra, M., McEntagart, M., Clayton-Smith, J., Platzer, K., Shukla, A., Girisha, K. M., ... & Genomics England Research Consortium. (2021). Heterozygous ANKRD17 loss-of-function variants cause a syndrome with intellectual disability, speech delay, and dysmorphism. The American Journal of Human Genetics.

Sidor, C., Borreguero-Munoz, N., Fletcher, G. C., Elbediwy, A., Guillermin, O., & Thompson, B. J. (2019). Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import and stability. Elife, 8, e48601.

D'Souza, W., Pradhan, S., & Saranath, D. (2017). Multiple single nucleotide polymorphism analysis and association of specific genotypes in FHIT, SAMD4A, and ANKRD17 in Indian patients with oral cancer. Head & neck, 39(8), 1586-1595.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-ANKRD17 Recombinant Antibody (2B8) (CAT#: CBMAB-A2777-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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