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Mouse Anti-ANXA8 Recombinant Antibody (C-11) (CBMAB-A2943-YC)

Provided herein is a Mouse monoclonal antibody against Human Annexin A8. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all ANXA8 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
C-11
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 120-154 within an internal region of Annexin VIII of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Annexin A8
Introduction
ANXA8 is a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene h
Entrez Gene ID
Human653145
Mouse11752
Rat306283
UniProt ID
HumanP13928
MouseO35640
RatQ4FZU6
Alternative Names
Annexin A8; Vascular Anticoagulant-Beta; Annexin VIII; Annexin-8; VAC-Beta; ANX8; CH17-360D5.2;
Function
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
Biological Process
Blood coagulation Source: UniProtKB-KW
Endosomal transport Source: UniProtKB
Endosome organization Source: UniProtKB
Negative regulation of phospholipase A2 activity Source: UniProtKB
Negative regulation of serine-type endopeptidase activity Source: UniProtKB
Cellular Location
Cytosol; Late endosome membrane; Plasma membrane; Collagen-containing extracellular matrix; Cytoplasm

Yuan, J. B., Gu, L., Chen, L., Yin, Y., & Fan, B. Y. (2021). Annexin A8 regulated by lncRNA-TUG1/miR-140-3p axis promotes bladder cancer progression and metastasis. Molecular Therapy-Oncolytics.

Lueck, K., Carr, A. J. F., Yu, L., Greenwood, J., & Moss, S. E. (2020). Annexin A8 regulates Wnt signaling to maintain the phenotypic plasticity of retinal pigment epithelial cells. Scientific reports, 10(1), 1-11.

Zhu, L., Gou, R., Guo, Q., Wang, J., Liu, Q., & Lin, B. (2020). High expression and potential synergy of human epididymis protein 4 and Annexin A8 promote progression and predict poor prognosis in epithelial ovarian cancer. American Journal of Translational Research, 12(7), 4017.

Gou, R., Zhu, L., Zheng, M., Guo, Q., Hu, Y., Li, X., ... & Lin, B. (2019). Annexin A8 can serve as potential prognostic biomarker and therapeutic target for ovarian cancer: based on the comprehensive analysis of Annexins. Journal of translational medicine, 17(1), 1-22.

Jiang, X., Xue, S., Kang, T., Liu, H., Ren, H., Hua, R., ... & Lei, M. (2019). Annexin A8 (ANXA8) regulates proliferation of porcine endometrial cells via Akt signalling pathway. Reproduction in Domestic Animals, 54(1), 3-10.

Scholz, P., Auler, M., Ruthard, J., Brachvogel, B., R Klatt, A., & Streichert, T. (2018). Detection of annexin A8 antibodies in serum of patients with antiphospholipid syndrome. Biochemia medica, 28(3), 415-419.

Lueck, K., Carr, A. J. F., Stampoulis, D., Gerke, V., Rescher, U., Greenwood, J., & Moss, S. E. (2017). Regulation of retinal pigment epithelial cell phenotype by Annexin A8. Scientific reports, 7(1), 1-13.

Heitzig, N., Brinkmann, B. F., Koerdt, S. N., Rosso, G., Shahin, V., & Rescher, U. (2017). Annexin A8 promotes VEGF-A driven endothelial cell sprouting. Cell adhesion & migration, 11(3), 275-287.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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