Human Recombinant ANXA8 protein, His Tag (V2LY-0526-LY2123)

Name: Human Recombinant ANXA8 protein, His Tag
SKU: V2LY-0526-LY2123
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant ANXA8 protein, His Tag consist of Amino Acid: 1-327 and predicts a molecular mass of 39.1 kDa.

Molecule Mass

39.1 kDa

Sequence

Amino Acid: 1-327

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Annexin A8

Function

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Biological Process

Blood coagulation Source: UniProtKB-KW
Endosomal transport Source: UniProtKB
Endosome organization Source: UniProtKB
Negative regulation of phospholipase A2 activity Source: UniProtKB
Negative regulation of serine-type endopeptidase activity Source: UniProtKB

Cellular Location

Cytosol; Late endosome membrane; Plasma membrane; Collagen-containing extracellular matrix; Cytoplasm

Yuan, J. B., Gu, L., Chen, L., Yin, Y., & Fan, B. Y. (2021). Annexin A8 regulated by lncRNA-TUG1/miR-140-3p axis promotes bladder cancer progression and metastasis. Molecular Therapy-Oncolytics.

Lueck, K., Carr, A. J. F., Yu, L., Greenwood, J., & Moss, S. E. (2020). Annexin A8 regulates Wnt signaling to maintain the phenotypic plasticity of retinal pigment epithelial cells. Scientific reports, 10(1), 1-11.

Zhu, L., Gou, R., Guo, Q., Wang, J., Liu, Q., & Lin, B. (2020). High expression and potential synergy of human epididymis protein 4 and Annexin A8 promote progression and predict poor prognosis in epithelial ovarian cancer. American Journal of Translational Research, 12(7), 4017.

Gou, R., Zhu, L., Zheng, M., Guo, Q., Hu, Y., Li, X., ... & Lin, B. (2019). Annexin A8 can serve as potential prognostic biomarker and therapeutic target for ovarian cancer: based on the comprehensive analysis of Annexins. Journal of translational medicine, 17(1), 1-22.

Jiang, X., Xue, S., Kang, T., Liu, H., Ren, H., Hua, R., ... & Lei, M. (2019). Annexin A8 (ANXA8) regulates proliferation of porcine endometrial cells via Akt signalling pathway. Reproduction in Domestic Animals, 54(1), 3-10.

Scholz, P., Auler, M., Ruthard, J., Brachvogel, B., R Klatt, A., & Streichert, T. (2018). Detection of annexin A8 antibodies in serum of patients with antiphospholipid syndrome. Biochemia medica, 28(3), 415-419.

Lueck, K., Carr, A. J. F., Stampoulis, D., Gerke, V., Rescher, U., Greenwood, J., & Moss, S. E. (2017). Regulation of retinal pigment epithelial cell phenotype by Annexin A8. Scientific reports, 7(1), 1-13.

Heitzig, N., Brinkmann, B. F., Koerdt, S. N., Rosso, G., Shahin, V., & Rescher, U. (2017). Annexin A8 promotes VEGF-A driven endothelial cell sprouting. Cell adhesion & migration, 11(3), 275-287.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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