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Mouse Anti-AREG Recombinant Antibody (A3413) (CBMAB-A3413-YC)

Provided herein is a Mouse monoclonal antibody against Human Amphiregulin. The antibody can be used for immunoassay techniques, such as WB, ICC, IHC-P, IHC-Fr, ELISA, IP, IF, FC.
See all AREG antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A3413
Antibody Isotype
IgG2b, κ
Application
WB, IHC-P

Basic Information

Immunogen
Recombinant protein Amphiregulin. The antigen corresponds to amino acid range 20-100 of the target protein.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB0.5-5 µg/ml
IHC-P5-30 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 50% glycerol
Preservative
0.05% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Amphiregulin
Introduction
AREG is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). T
Entrez Gene ID
374
UniProt ID
P15514
Alternative Names
Amphiregulin; Colorectum Cell-Derived Growth Factor; Schwannoma-Derived Growth Factor; Amphiregulin B; AREGB; CRDGF; SDGF; AR;
Function
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Biological Process
Cell-cell signaling Source: ProtInc
COPII vesicle coating Source: Reactome
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Epidermal growth factor receptor signaling pathway Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: BHF-UCL
MAPK cascade Source: Reactome
Membrane organization Source: Reactome
Negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of epidermal growth factor-activated receptor activity Source: GO_Central
Positive regulation of keratinocyte proliferation Source: GO_Central
Positive regulation of protein kinase B signaling Source: Reactome
Signal transduction Source: Reactome
Cellular Location
Membrane
Topology
Helical: 199-221 aa

Hachim, M. Y., Elemam, N. M., Ramakrishnan, R. K., Salameh, L., Olivenstein, R., Hachim, I. Y., ... & Hamoudi, R. (2020). Blood and salivary amphiregulin levels as biomarkers for asthma. Frontiers in Medicine, 7.

Todd, J. L., Kelly, F. L., Nagler, A., Banner, K., Pavlisko, E. N., Belperio, J. A., ... & Palmer, S. M. (2020). Amphiregulin contributes to airway remodeling in chronic allograft dysfunction after lung transplantation. American Journal of Transplantation, 20(3), 825-833.

Santamaría, E., Rodríguez‐Ortigosa, C. M., Uriarte, I., Latasa, M. U., Urtasun, R., Alvarez‐Sola, G., ... & Berasain, C. (2019). The epidermal growth factor receptor ligand amphiregulin protects from cholestatic liver injury and regulates bile acids synthesis. Hepatology, 69(4), 1632-1647.

Steponaitis, G., Kazlauskas, A., Skiriute, D., Vaitkiene, P., Skauminas, K., & Tamasauskas, A. (2019). Significance of amphiregulin (AREG) for the outcome of low and high grade astrocytoma patients. Journal of Cancer, 10(6), 1479.

Raimondo, S., Saieva, L., Vicario, E., Pucci, M., Toscani, D., Manno, M., ... & Alessandro, R. (2019). Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis. Journal of hematology & oncology, 12(1), 1-15.

Xu, Q., Long, Q., Zhu, D., Fu, D., Zhang, B., Han, L., ... & Sun, Y. (2019). Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD‐L1)‐mediated immunosuppression. Aging cell, 18(6), e13027.

Dogan, M., Sahin, M., & Yenisey, C. (2019). Increased TSLP, IL-33, IL-25, IL-19, IL 21 and amphiregulin (AREG) levels in chronic rhinosinusitis with nasal polyp. European Archives of Oto-Rhino-Laryngology, 276(6), 1685-1691.

Wang, J., Zhu, M., Wang, L., Chen, C., & Song, Y. (2019). Amphiregulin potentiates airway inflammation and mucus hypersecretion induced by urban particulate matter via the EGFR-PI3Kα-AKT/ERK pathway. Cellular signalling, 53, 122-131.

Vermillion, M. S., Ursin, R. L., Kuok, D. I., Vom Steeg, L. G., Wohlgemuth, N., Hall, O. J., ... & Klein, S. L. (2018). Production of amphiregulin and recovery from influenza is greater in males than females. Biology of sex differences, 9(1), 1-12.

Tung, S. L., Huang, W. C., Hsu, F. C., Yang, Z. P., Jang, T. H., Chang, J. W., ... & Wang, L. H. (2017). miRNA-34c-5p inhibits amphiregulin-induced ovarian cancer stemness and drug resistance via downregulation of the AREG-EGFR-ERK pathway. Oncogenesis, 6(5), e326-e326.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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