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AREG

The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]
Full Name
Amphiregulin
Function
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Biological Process
Cell-cell signaling Source: ProtInc
COPII vesicle coating Source: Reactome
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Epidermal growth factor receptor signaling pathway Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: BHF-UCL
MAPK cascade Source: Reactome
Membrane organization Source: Reactome
Negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of epidermal growth factor-activated receptor activity Source: GO_Central
Positive regulation of keratinocyte proliferation Source: GO_Central
Positive regulation of protein kinase B signaling Source: Reactome
Signal transduction Source: Reactome
Cellular Location
Membrane
Topology
Helical: 199-221 aa
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Anti-AREG antibodies

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Mouse Anti-AREG Recombinant Antibody (CAP174) (CBMAB-AP421LY)

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Target: AREG
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CAP174
Application*: E, IF, P, WB
Datasheet SDS

Rat Anti-AREG Recombinant Antibody (CBYC-A737) (CBMAB-A3415-YC)

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Target: AREG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYC-A737
Application*: WB
Datasheet SDS

Mouse Anti-AREG Recombinant Antibody (A3413) (CBMAB-A3413-YC)

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Target: AREG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: A3413
Application*: WB, P
Datasheet SDS

Rat Anti-AREG Recombinant Antibody (7D17) (CBMAB-A3412-YC)

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Target: AREG
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 7D17
Application*: WB
Datasheet SDS

Mouse Anti-AREG Recombinant Antibody (31221) (CBMAB-A3410-YC)

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Target: AREG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 31221
Application*: WB, N, E
Functional Assay
Datasheet SDS

Mouse Anti-AREG Recombinant Antibody (1A1G9) (CBMAB-A3409-YC)

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Target: AREG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 1A1G9
Application*: WB, IH
Datasheet SDS

Mouse Anti-AREG Recombinant Antibody (CBLNA-115) (CBMAB-1131-CN)

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Target: AREG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBLNA-115
Application*: E, IF, IP, WB, P
Datasheet SDS

Mouse Anti-AREG Recombinant Antibody (3E4) (CBMAB-1130-CN)

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Target: AREG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3E4
Application*: WB, E
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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