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AREG

The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]
Full Name
Amphiregulin
Function
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Biological Process
Cell-cell signaling Source: ProtInc
COPII vesicle coating Source: Reactome
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Epidermal growth factor receptor signaling pathway Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: BHF-UCL
MAPK cascade Source: Reactome
Membrane organization Source: Reactome
Negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of epidermal growth factor-activated receptor activity Source: GO_Central
Positive regulation of keratinocyte proliferation Source: GO_Central
Positive regulation of protein kinase B signaling Source: Reactome
Signal transduction Source: Reactome
Cellular Location
Membrane
Topology
Helical: 199-221 aa

Anti-AREG antibodies

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Target: AREG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBLNA-115
Application*: E, IF, IP, WB, P
Target: AREG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3E4
Application*: WB, E
Target: AREG
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CAP174
Application*: E, IF, P, WB
Target: AREG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYC-A737
Application*: WB
Target: AREG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: A3413
Application*: WB, P
Target: AREG
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 7D17
Application*: WB
Target: AREG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 31221
Application*: WB, N, E
Target: AREG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 1A1G9
Application*: WB, IH
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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