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Mouse Anti-ARNT2 Antibody (B11) (CBMAB-0131-YC)

Provided herein are mouse monoclonal antibodies against Human ARNT2. The antibody clone 1A3 can be used for immunoassay techniques, such as IP and MA.
See all ARNT2 antibodies
Published Data
Mouse Anti-ARNT2 Antibody (B11) CBMAB-0131-YC in WB
Western blotting of 0 h time point were used to assess effectiveness of knockdown. ...View More
Fortenbery, G. W., Sarathy, B., Carraway, K. R., & Mansfield, K. D. (2018). Hypoxic stabilization of mRNA is HIF-independent but requires mtROS. Cellular & Molecular Biology Letters, 23(1), 1-15.
Mouse Anti-ARNT2 Antibody (B11) CBMAB-0131-YC in WB
WB analysis of ARNT1, ARNT2, ARNTL1, NPAS4, and β-actin from CA1 lysates. Stimulation, pharmacology, and time post-stimulation are indicated. ...View More
Brigidi, G. S., Hayes, M. G., Santos, N. P. D., Hartzell, A. L., Texari, L., Lin, P. A., ... & Bloodgood, B. L. (2019). Genomic decoding of neuronal depolarization by stimulus-specific NPAS4 heterodimers. Cell, 179(2), 373-391.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Cattle, Pig, Dog, Horse
Clone
B11
Antibody Isotype
IgG2b
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 683-712 at the C-terminus of Arnt 2 of mouse origin.
Specificity
Human, Mouse, Rat, Cattle, Pig, Dog, Horse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Aryl Hydrocarbon Receptor Nuclear Translocator 2
Introduction
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) is a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli.
Entrez Gene ID
Human9915
Mouse11864
Rat25243
UniProt ID
HumanQ9HBZ2
MouseQ61324
RatQ78E60
Alternative Names
bHLHe1; KIAA0307
Function
Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475).
Specifically recognizes the xenobiotic response element (XRE).
Biological Process
Brain development Source: UniProtKB
Central nervous system development Source: UniProtKB
In utero embryonic development Source: UniProtKB
Negative regulation of apoptotic process Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription, DNA-templated Source: MGI
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to estradiol Source: Ensembl
Response to hypoxia Source: UniProtKB
Xenobiotic metabolic process Source: Reactome
Cellular Location
Nucleus
Involvement in disease
Webb-Dattani syndrome (WEDAS): A disorder characterized by postnatal microcephaly with fronto-temporal lobe hypoplasia, multiple pituitary hormone deficiency, global developmental delay, seizures, severe visual impairment and abnormalities of the kidneys and urinary tract.

Doering, J. A., Beitel, S. C., Patterson, S., Eisner, B. K., Giesy, J. P., Hecker, M., & Wiseman, S. (2020). Aryl hydrocarbon receptor nuclear translocators (ARNT1, ARNT2, and ARNT3) of white sturgeon (Acipenser transmontanus): Sequences, tissue-specific expressions, and response to β-naphthoflavone. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 231, 108726.

Becquart, P., Johnston, J., Vilariño-Güell, C., & Quandt, J. A. (2020). Oligodendrocyte ARNT2 expression is altered in models of MS. Neurology-Neuroimmunology Neuroinflammation, 7(4).

Pei, C. D., Zhang, L. L., Fei, P. G., Gu, S. N., Li, W. Q., Mu, J. L., ... & Song, J. G. (2019). Upregulation of aryl hydrocarbon receptor nuclear translocator 2 in the hippocampi of post‑stroke depression rats. Biomedical reports, 11(2), 51-58.

Rahman, M. S., & Thomas, P. (2019). Molecular cloning and characterization of two ARNT (ARNT‐1 and ARNT‐2) genes in Atlantic croaker and their expression during coexposure to hypoxia and PCB77. Environmental toxicology, 34(2), 160-171.

Jia, Y., Hao, S., Jin, G., Li, H., Ma, X., Zheng, Y., ... & Wang, Y. (2019). Overexpression of ARNT2 is associated with decreased cell proliferation and better prognosis in gastric cancer. Molecular and cellular biochemistry, 450(1), 97-103.

Rahim, T., Becquart, P., Baeva, M. E., & Quandt, J. (2018). Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis. Journal of neuroinflammation, 15(1), 1-17.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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