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Mouse Anti-ARNT2 Recombinant Antibody (3E12) (CBMAB-A0492-LY)

The product is antibody recognizes ARNT2. The antibody 3E12 immunoassay techniques such as: sELISA, ELISA.
See all ARNT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3E12
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
ARNT2 (AAH36099, 1 a.a. ~ 716 a.a) full-length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Aryl Hydrocarbon Receptor Nuclear Translocator 2
Introduction
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq]
Entrez Gene ID
9915
UniProt ID
Q9HBZ2
Alternative Names
KIAA0307; bHLHe1
Function
Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475).
Specifically recognizes the xenobiotic response element (XRE).
Biological Process
Brain development Source: UniProtKB
Central nervous system development Source: UniProtKB
In utero embryonic development Source: UniProtKB
Negative regulation of apoptotic process Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription, DNA-templated Source: MGI
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to estradiol Source: Ensembl
Response to hypoxia Source: UniProtKB
Xenobiotic metabolic process Source: Reactome
Cellular Location
Nucleus
Involvement in disease
Webb-Dattani syndrome (WEDAS): A disorder characterized by postnatal microcephaly with fronto-temporal lobe hypoplasia, multiple pituitary hormone deficiency, global developmental delay, seizures, severe visual impairment and abnormalities of the kidneys and urinary tract.

Doering, J. A., Beitel, S. C., Patterson, S., Eisner, B. K., Giesy, J. P., Hecker, M., & Wiseman, S. (2020). Aryl hydrocarbon receptor nuclear translocators (ARNT1, ARNT2, and ARNT3) of white sturgeon (Acipenser transmontanus): Sequences, tissue-specific expressions, and response to β-naphthoflavone. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 231, 108726.

Becquart, P., Johnston, J., Vilariño-Güell, C., & Quandt, J. A. (2020). Oligodendrocyte ARNT2 expression is altered in models of MS. Neurology-Neuroimmunology Neuroinflammation, 7(4).

Pei, C. D., Zhang, L. L., Fei, P. G., Gu, S. N., Li, W. Q., Mu, J. L., ... & Song, J. G. (2019). Upregulation of aryl hydrocarbon receptor nuclear translocator 2 in the hippocampi of post‑stroke depression rats. Biomedical reports, 11(2), 51-58.

Rahman, M. S., & Thomas, P. (2019). Molecular cloning and characterization of two ARNT (ARNT‐1 and ARNT‐2) genes in Atlantic croaker and their expression during coexposure to hypoxia and PCB77. Environmental toxicology, 34(2), 160-171.

Jia, Y., Hao, S., Jin, G., Li, H., Ma, X., Zheng, Y., ... & Wang, Y. (2019). Overexpression of ARNT2 is associated with decreased cell proliferation and better prognosis in gastric cancer. Molecular and cellular biochemistry, 450(1), 97-103.

Rahim, T., Becquart, P., Baeva, M. E., & Quandt, J. (2018). Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis. Journal of neuroinflammation, 15(1), 1-17.

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For research use only. Not intended for any clinical use.

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