Mouse Anti-ARNT2 Recombinant Antibody (B-5) (CBMAB-A3641-YC)

Name: Mouse Anti-ARNT2 Recombinant Antibody (B-5)
SKU: CBMAB-A3641-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

B-5

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 679-712 at the C-terminus of Arnt 2 of mouse origin.

Specificity

Human, Mouse, Rat, Cattle, Pig, Dog, Horse

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Aryl Hydrocarbon Receptor Nuclear Translocator 2

Introduction

ARNT2 is a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind

Entrez Gene ID

Human	9915
Mouse	11864
Rat	25243

UniProt ID

Human	Q9HBZ2
Mouse	Q61324
Rat	Q78E60

Alternative Names

Aryl Hydrocarbon Receptor Nuclear Translocator 2; Class E Basic Helix-Loop-Helix Protein 1; ARNT Protein 2; BHLHe1; KIAA0307; WEDAS;

Function

Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475).
Specifically recognizes the xenobiotic response element (XRE).

Biological Process

Brain development Source: UniProtKB
Central nervous system development Source: UniProtKB
In utero embryonic development Source: UniProtKB
Negative regulation of apoptotic process Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription, DNA-templated Source: MGI
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to estradiol Source: Ensembl
Response to hypoxia Source: UniProtKB
Xenobiotic metabolic process Source: Reactome

Cellular Location

Nucleus

Involvement in disease

Webb-Dattani syndrome (WEDAS): A disorder characterized by postnatal microcephaly with fronto-temporal lobe hypoplasia, multiple pituitary hormone deficiency, global developmental delay, seizures, severe visual impairment and abnormalities of the kidneys and urinary tract.

Doering, J. A., Beitel, S. C., Patterson, S., Eisner, B. K., Giesy, J. P., Hecker, M., & Wiseman, S. (2020). Aryl hydrocarbon receptor nuclear translocators (ARNT1, ARNT2, and ARNT3) of white sturgeon (Acipenser transmontanus): Sequences, tissue-specific expressions, and response to β-naphthoflavone. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 231, 108726.

Becquart, P., Johnston, J., Vilariño-Güell, C., & Quandt, J. A. (2020). Oligodendrocyte ARNT2 expression is altered in models of MS. Neurology-Neuroimmunology Neuroinflammation, 7(4).

Pei, C. D., Zhang, L. L., Fei, P. G., Gu, S. N., Li, W. Q., Mu, J. L., ... & Song, J. G. (2019). Upregulation of aryl hydrocarbon receptor nuclear translocator 2 in the hippocampi of post‑stroke depression rats. Biomedical reports, 11(2), 51-58.

Rahman, M. S., & Thomas, P. (2019). Molecular cloning and characterization of two ARNT (ARNT‐1 and ARNT‐2) genes in Atlantic croaker and their expression during coexposure to hypoxia and PCB77. Environmental toxicology, 34(2), 160-171.

Jia, Y., Hao, S., Jin, G., Li, H., Ma, X., Zheng, Y., ... & Wang, Y. (2019). Overexpression of ARNT2 is associated with decreased cell proliferation and better prognosis in gastric cancer. Molecular and cellular biochemistry, 450(1), 97-103.

Rahim, T., Becquart, P., Baeva, M. E., & Quandt, J. (2018). Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis. Journal of neuroinflammation, 15(1), 1-17.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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