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Rat Anti-ARTN Recombinant Antibody (RM0074-6G32) (CBMAB-1143-CN)

This product is a rat antibody that recognizes ARTN of mouse. The antibody RM0074-6G32 can be used for immunoassay techniques such as: WB, IHC-Fr.
See all ARTN antibodies
Published Data
Fig.1 Flow cytometry analysis of LSK cells in the absence or presence of GDNF, NRTN or ARTN for 1 h.
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Fig.2 H&E staining of artemin in skin from healthy donors and patients with AD.
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Fig.3 Immunostaining of artemin in skin from healthy donors and patients with AD.
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Summary

Host Animal
Rat
Specificity
Mouse
Clone
RM0074-6G32
Antibody Isotype
IgG2
Application
IHC, WB

Basic Information

Immunogen
Mouse recombinant Artemin.
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:50-1:200
IHC1:10-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Artemin
Introduction
Aryl hydrocarbon receptor nuclear translocator (ARNT) protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1) and forms a complex with ligand-bound aryl hydrocarbon receptor (AhR). It is required for receptor function.
Entrez Gene ID
11876
UniProt ID
Q9Z0L2
Alternative Names
neublastin
Function
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.
Biological Process
Axon guidance Source: Reactome
Induction of positive chemotaxis Source: Ensembl
Lymphocyte migration into lymphoid organs Source: Ensembl
MAPK cascade Source: Reactome
Neuroblast proliferation Source: ProtInc
Peripheral nervous system development Source: GO_Central
Peyer's patch morphogenesis Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Secreted

Gupta, A., Chiavaccini, L., Minnema, L. M., Chiu, K. W., Knazovicky, D., Hash, J. A., ... & Lascelles, B. D. X. (2021). Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain. Scientific reports, 11(1), 1-11.

Huang, H. M., Huang, C. C., Poon, L. Y. C., & Chang, Y. C. (2021). Artemin Is Upregulated by TrkB Agonist and Protects the Immature Retina Against Hypoxic-Ischemic Injury by Suppressing Neuroinflammation and Astrogliosis. Frontiers in molecular neuroscience, 14, 56.

Zhu, S., Li, Y., Bennett, S., Chen, J., Weng, I. Z., Huang, L., ... & Xu, J. (2020). The role of glial cell line‐derived neurotrophic factor family member artemin in neurological disorders and cancers. Cell proliferation, 53(7), e12860.

Feng, S., Sim, H. W., Bucur, R., Aggarwal, R., Abreu, P., Ray, M., ... & Chen, E. X. (2020). Preoperative serum artemin (ARTN) as a predictive biomarker of recurrence following curative resection for hepatocellular carcinoma (HCC).

Odesina, P. A. O. (2019). Determination of the Relationship Between Artemin Expression Levels in Blood and Breast Cancer (Doctoral dissertation, Auckland University of Technology).

Ilieva, M., Nielsen, J., Korshunova, I., Gotfryd, K., Bock, E., Pankratova, S., & Michel, T. M. (2019). Artemin and an artemin-derived peptide, artefin, induce neuronal survival, and differentiation through RET and NCAM. Frontiers in molecular neuroscience, 12, 47.

Edamitsu, T., Taguchi, K., Kobayashi, E. H., Okuyama, R., & Yamamoto, M. (2019). Aryl hydrocarbon receptor directly regulates artemin gene expression. Molecular and cellular biology, 39(20), e00190-19.

Hezam, K., Jiang, J., Sun, F., Zhang, X., & Zhang, J. (2018). Artemin promotes oncogenicity, metastasis and drug resistance in cancer cells. Reviews in the Neurosciences, 29(1), 93-98.

Matsumoto, A., Murota, H., Terao, M., & Katayama, I. (2018). Attenuated activation of homeostatic glucocorticoid in keratinocytes induces alloknesis via aberrant artemin production. Journal of Investigative Dermatology, 138(7), 1491-1500.

Hidaka, T., Ogawa, E., Kobayashi, E. H., Suzuki, T., Funayama, R., Nagashima, T., ... & Yamamoto, M. (2017). The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin. Nature immunology, 18(1), 64-73.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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