Rat Anti-ARTN Recombinant Antibody (RM0074-6G32) (CBMAB-1143-CN)

Name: Rat Anti-ARTN Recombinant Antibody (RM0074-6G32)
SKU: CBMAB-1143-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

RM0074-6G32

Application

IHC, WB

Immunogen

Mouse recombinant Artemin.

Specificity

Mouse

Antibody Isotype

IgG2

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:50-1:200
IHC	1:10-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Artemin

Introduction

Aryl hydrocarbon receptor nuclear translocator (ARNT) protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1) and forms a complex with ligand-bound aryl hydrocarbon receptor (AhR). It is required for receptor function.

Entrez Gene ID

11876

UniProt ID

Q9Z0L2

Alternative Names

neublastin

Function

Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.

Biological Process

Axon guidance Source: Reactome
Induction of positive chemotaxis Source: Ensembl
Lymphocyte migration into lymphoid organs Source: Ensembl
MAPK cascade Source: Reactome
Neuroblast proliferation Source: ProtInc
Peripheral nervous system development Source: GO_Central
Peyer's patch morphogenesis Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Secreted

Gupta, A., Chiavaccini, L., Minnema, L. M., Chiu, K. W., Knazovicky, D., Hash, J. A., ... & Lascelles, B. D. X. (2021). Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain. Scientific reports, 11(1), 1-11.

Huang, H. M., Huang, C. C., Poon, L. Y. C., & Chang, Y. C. (2021). Artemin Is Upregulated by TrkB Agonist and Protects the Immature Retina Against Hypoxic-Ischemic Injury by Suppressing Neuroinflammation and Astrogliosis. Frontiers in molecular neuroscience, 14, 56.

Zhu, S., Li, Y., Bennett, S., Chen, J., Weng, I. Z., Huang, L., ... & Xu, J. (2020). The role of glial cell line‐derived neurotrophic factor family member artemin in neurological disorders and cancers. Cell proliferation, 53(7), e12860.

Feng, S., Sim, H. W., Bucur, R., Aggarwal, R., Abreu, P., Ray, M., ... & Chen, E. X. (2020). Preoperative serum artemin (ARTN) as a predictive biomarker of recurrence following curative resection for hepatocellular carcinoma (HCC).

Odesina, P. A. O. (2019). Determination of the Relationship Between Artemin Expression Levels in Blood and Breast Cancer (Doctoral dissertation, Auckland University of Technology).

Ilieva, M., Nielsen, J., Korshunova, I., Gotfryd, K., Bock, E., Pankratova, S., & Michel, T. M. (2019). Artemin and an artemin-derived peptide, artefin, induce neuronal survival, and differentiation through RET and NCAM. Frontiers in molecular neuroscience, 12, 47.

Edamitsu, T., Taguchi, K., Kobayashi, E. H., Okuyama, R., & Yamamoto, M. (2019). Aryl hydrocarbon receptor directly regulates artemin gene expression. Molecular and cellular biology, 39(20), e00190-19.

Hezam, K., Jiang, J., Sun, F., Zhang, X., & Zhang, J. (2018). Artemin promotes oncogenicity, metastasis and drug resistance in cancer cells. Reviews in the Neurosciences, 29(1), 93-98.

Matsumoto, A., Murota, H., Terao, M., & Katayama, I. (2018). Attenuated activation of homeostatic glucocorticoid in keratinocytes induces alloknesis via aberrant artemin production. Journal of Investigative Dermatology, 138(7), 1491-1500.

Hidaka, T., Ogawa, E., Kobayashi, E. H., Suzuki, T., Funayama, R., Nagashima, T., ... & Yamamoto, M. (2017). The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin. Nature immunology, 18(1), 64-73.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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