Mouse Recombinant ARTN protein, hFc Tag (V2LY-0526-LY7825)

Name: Mouse Recombinant ARTN protein, hFc Tag
SKU: V2LY-0526-LY7825
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

hFc Tag

Protein Construction

This product is Mouse Recombinant ARTN protein, hFc Tag consist of Amino Acid: 112-224 and predicts a molecular mass of 40.6 kDa.

Molecule Mass

40.6 kDa

Sequence

Amino Acid: 112-224

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Artemin

Function

Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.

Biological Process

Axon guidance Source: Reactome
Induction of positive chemotaxis Source: Ensembl
Lymphocyte migration into lymphoid organs Source: Ensembl
MAPK cascade Source: Reactome
Neuroblast proliferation Source: ProtInc
Peripheral nervous system development Source: GO_Central
Peyer's patch morphogenesis Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Secreted

Gupta, A., Chiavaccini, L., Minnema, L. M., Chiu, K. W., Knazovicky, D., Hash, J. A., ... & Lascelles, B. D. X. (2021). Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain. Scientific reports, 11(1), 1-11.

Huang, H. M., Huang, C. C., Poon, L. Y. C., & Chang, Y. C. (2021). Artemin Is Upregulated by TrkB Agonist and Protects the Immature Retina Against Hypoxic-Ischemic Injury by Suppressing Neuroinflammation and Astrogliosis. Frontiers in molecular neuroscience, 14, 56.

Zhu, S., Li, Y., Bennett, S., Chen, J., Weng, I. Z., Huang, L., ... & Xu, J. (2020). The role of glial cell line‐derived neurotrophic factor family member artemin in neurological disorders and cancers. Cell proliferation, 53(7), e12860.

Feng, S., Sim, H. W., Bucur, R., Aggarwal, R., Abreu, P., Ray, M., ... & Chen, E. X. (2020). Preoperative serum artemin (ARTN) as a predictive biomarker of recurrence following curative resection for hepatocellular carcinoma (HCC).

Odesina, P. A. O. (2019). Determination of the Relationship Between Artemin Expression Levels in Blood and Breast Cancer (Doctoral dissertation, Auckland University of Technology).

Ilieva, M., Nielsen, J., Korshunova, I., Gotfryd, K., Bock, E., Pankratova, S., & Michel, T. M. (2019). Artemin and an artemin-derived peptide, artefin, induce neuronal survival, and differentiation through RET and NCAM. Frontiers in molecular neuroscience, 12, 47.

Edamitsu, T., Taguchi, K., Kobayashi, E. H., Okuyama, R., & Yamamoto, M. (2019). Aryl hydrocarbon receptor directly regulates artemin gene expression. Molecular and cellular biology, 39(20), e00190-19.

Hezam, K., Jiang, J., Sun, F., Zhang, X., & Zhang, J. (2018). Artemin promotes oncogenicity, metastasis and drug resistance in cancer cells. Reviews in the Neurosciences, 29(1), 93-98.

Matsumoto, A., Murota, H., Terao, M., & Katayama, I. (2018). Attenuated activation of homeostatic glucocorticoid in keratinocytes induces alloknesis via aberrant artemin production. Journal of Investigative Dermatology, 138(7), 1491-1500.

Hidaka, T., Ogawa, E., Kobayashi, E. H., Suzuki, T., Funayama, R., Nagashima, T., ... & Yamamoto, M. (2017). The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin. Nature immunology, 18(1), 64-73.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human ARTN ELISA Kit (CAT#: V2LY-0626-LY3463)

Related Products

Rat Anti-ARTN Recombinant Antibody (BA0379) (CAT#: CBMAB-0101CQ)

Human ARTN ELISA Kit (CAT#: V2LY-0626-LY3463)

Rat Anti-ARTN Recombinant Antibody (RM0074-6G32) (CAT#: CBMAB-1143-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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