Human ARTN ELISA Kit (V2LY-0626-LY3463)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.1 ng/mL
Detection Range
0.2-60 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
22.9 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Artemin
Function
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.
Biological Process
Axon guidance Source: Reactome
Induction of positive chemotaxis Source: Ensembl
Lymphocyte migration into lymphoid organs Source: Ensembl
MAPK cascade Source: Reactome
Neuroblast proliferation Source: ProtInc
Peripheral nervous system development Source: GO_Central
Peyer's patch morphogenesis Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Secreted

Gupta, A., Chiavaccini, L., Minnema, L. M., Chiu, K. W., Knazovicky, D., Hash, J. A., ... & Lascelles, B. D. X. (2021). Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain. Scientific reports, 11(1), 1-11.

Huang, H. M., Huang, C. C., Poon, L. Y. C., & Chang, Y. C. (2021). Artemin Is Upregulated by TrkB Agonist and Protects the Immature Retina Against Hypoxic-Ischemic Injury by Suppressing Neuroinflammation and Astrogliosis. Frontiers in molecular neuroscience, 14, 56.

Zhu, S., Li, Y., Bennett, S., Chen, J., Weng, I. Z., Huang, L., ... & Xu, J. (2020). The role of glial cell line‐derived neurotrophic factor family member artemin in neurological disorders and cancers. Cell proliferation, 53(7), e12860.

Feng, S., Sim, H. W., Bucur, R., Aggarwal, R., Abreu, P., Ray, M., ... & Chen, E. X. (2020). Preoperative serum artemin (ARTN) as a predictive biomarker of recurrence following curative resection for hepatocellular carcinoma (HCC).

Odesina, P. A. O. (2019). Determination of the Relationship Between Artemin Expression Levels in Blood and Breast Cancer (Doctoral dissertation, Auckland University of Technology).

Ilieva, M., Nielsen, J., Korshunova, I., Gotfryd, K., Bock, E., Pankratova, S., & Michel, T. M. (2019). Artemin and an artemin-derived peptide, artefin, induce neuronal survival, and differentiation through RET and NCAM. Frontiers in molecular neuroscience, 12, 47.

Edamitsu, T., Taguchi, K., Kobayashi, E. H., Okuyama, R., & Yamamoto, M. (2019). Aryl hydrocarbon receptor directly regulates artemin gene expression. Molecular and cellular biology, 39(20), e00190-19.

Hezam, K., Jiang, J., Sun, F., Zhang, X., & Zhang, J. (2018). Artemin promotes oncogenicity, metastasis and drug resistance in cancer cells. Reviews in the Neurosciences, 29(1), 93-98.

Matsumoto, A., Murota, H., Terao, M., & Katayama, I. (2018). Attenuated activation of homeostatic glucocorticoid in keratinocytes induces alloknesis via aberrant artemin production. Journal of Investigative Dermatology, 138(7), 1491-1500.

Hidaka, T., Ogawa, E., Kobayashi, E. H., Suzuki, T., Funayama, R., Nagashima, T., ... & Yamamoto, M. (2017). The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin. Nature immunology, 18(1), 64-73.

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For research use only. Not intended for any clinical use.

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