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Mouse Anti-ASB2 Recombinant Antibody (1E5) (CBMAB-A3717-YC)

Provided herein is a Mouse monoclonal antibody against Human Ankyrin Repeat And SOCS Box Containing 2. The antibody can be used for immunoassay techniques, such as ELISA.
See all ASB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E5
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Immunogen
Full length recombinant corresponding to aa1-588, from humuan ASB2 (AAH32354, 51676) with GST tag.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ankyrin repeat and SOCS box-containing 2
Introduction
ASB2 is a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subu
Entrez Gene ID
51676
UniProt ID
Q96Q27
Alternative Names
Ankyrin Repeat And SOCS Box Containing 2; ASB-2; Ankyrin Repeat And SOCS Box-Containing Protein 2a; Ankyrin Repeat And SOCS Box-Containing 2; Ankyrin Repeat And SOCS Box Protein 2;
Function
Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Isoform 1: Enhances adhesion of hematopoietic cells to fibronectin through targeting of filamins FLNA and FLNB for proteasomal degradation, it is transiantly expressed during hematopoietic cell differentiation.
Isoform 2: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA.
Biological Process
Intracellular signal transduction Source: InterPro
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB
Signal transduction Source: ProtInc
Skeletal muscle cell differentiation Source: Ensembl
Ubiquitin-dependent protein catabolic process Source: GO_Central
Cellular Location
Cytosol; Ubiquitin ligase complex
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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