Human ASB2 ELISA Kit (V2LY-0626-LY4353)

Name: Human ASB2 ELISA Kit
SKU: V2LY-0626-LY4353
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.003 ng/mL

Detection Range

0.005-1 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

65.1 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

ankyrin repeat and SOCS box-containing 2

Function

Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Isoform 1: Enhances adhesion of hematopoietic cells to fibronectin through targeting of filamins FLNA and FLNB for proteasomal degradation, it is transiantly expressed during hematopoietic cell differentiation.
Isoform 2: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA.

Biological Process

Intracellular signal transduction Source: InterPro
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB
Signal transduction Source: ProtInc
Skeletal muscle cell differentiation Source: Ensembl
Ubiquitin-dependent protein catabolic process Source: GO_Central

Cellular Location

Cytosol; Ubiquitin ligase complex

Mamoor, S. (2021). Differential expression of ankyrin repeat and SOCS box-containing 2 in human epithelial ovarian cancer.

Shin, J. H., Moreno-Nieves, U. Y., Zhang, L. H., Chen, C., Dixon, A. L., Linde, M. H., ... & Sunwoo, J. B. (2021). AHR Regulates NK Cell Migration via ASB2–Mediated Ubiquitination of Filamin A. Frontiers in Immunology, 12.

Park, S. G., Kim, E. K., Nam, K. H., Lee, J. G., Baek, I. J., Lee, B. J., & Nam, S. Y. (2021). Heart defects and embryonic lethality in Asb2 knock out mice correlate with placental defects. Cells and Development, 165, 203663.

Wu, W., Nie, L., Zhang, L., & Li, Y. (2018). The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells. Cellular & molecular biology letters, 23(1), 1-13.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Asb2 ELISA Kit (CAT#: V2LY-0626-LY2056)

Related Products

Rat Asb2 ELISA Kit (CAT#: V2LY-0626-LY2056)

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Mouse Anti-ASB2 Recombinant Antibody (1E5) (CAT#: CBMAB-A3717-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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