Mouse Anti-ASB2 Recombinant Antibody (4C2) (CBMAB-A3719-YC)

Name: Mouse Anti-ASB2 Recombinant Antibody (4C2)
SKU: CBMAB-A3719-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4C2

Application

WB, IHC

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-300 of human ASB2 produced in E. coli

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500
IHC	1:150

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ankyrin repeat and SOCS box-containing 2

Introduction

ASB2 is a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subu

Entrez Gene ID

51676

UniProt ID

Q96Q27

Alternative Names

Ankyrin Repeat And SOCS Box Containing 2; ASB-2; Ankyrin Repeat And SOCS Box-Containing Protein 2a; Ankyrin Repeat And SOCS Box-Containing 2; Ankyrin Repeat And SOCS Box Protein 2;

Function

Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Isoform 1: Enhances adhesion of hematopoietic cells to fibronectin through targeting of filamins FLNA and FLNB for proteasomal degradation, it is transiantly expressed during hematopoietic cell differentiation.
Isoform 2: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA.

Biological Process

Intracellular signal transduction Source: InterPro
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB
Signal transduction Source: ProtInc
Skeletal muscle cell differentiation Source: Ensembl
Ubiquitin-dependent protein catabolic process Source: GO_Central

Cellular Location

Cytosol; Ubiquitin ligase complex

Mamoor, S. (2021). Differential expression of ankyrin repeat and SOCS box-containing 2 in human epithelial ovarian cancer.

Shin, J. H., Moreno-Nieves, U. Y., Zhang, L. H., Chen, C., Dixon, A. L., Linde, M. H., ... & Sunwoo, J. B. (2021). AHR Regulates NK Cell Migration via ASB2–Mediated Ubiquitination of Filamin A. Frontiers in Immunology, 12.

Park, S. G., Kim, E. K., Nam, K. H., Lee, J. G., Baek, I. J., Lee, B. J., & Nam, S. Y. (2021). Heart defects and embryonic lethality in Asb2 knock out mice correlate with placental defects. Cells and Development, 165, 203663.

Wu, W., Nie, L., Zhang, L., & Li, Y. (2018). The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells. Cellular & molecular biology letters, 23(1), 1-13.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-ASB2 Recombinant Antibody (2A2) (CAT#: CBMAB-A3718-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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