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Mouse Anti-ATP5F1B Recombinant Antibody (6C4) (CBMAB-A4055-YC)

Provided herein is a Mouse monoclonal antibody against Human ATP Synthase F1 Subunit Beta. The antibody can be used for immunoassay techniques, such as FC, ICC, IF, IHC, IHC-P, WB.
See all ATP5F1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6C4
Antibody Isotype
IgG1
Application
FC, ICC, IF, IHC, WB

Basic Information

Immunogen
Full length human recombinant protein of human ATP5B produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IHC1:50
FC1:100
IF(ICC)1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATP Synthase F1 Subunit Beta
Introduction
ATP5F1B is a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked mul
Entrez Gene ID
506
UniProt ID
P06576
Alternative Names
ATP Synthase F1 Subunit Beta; ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Beta Polypeptide; ATP5B; EC 3.6.3.14; ATPSB; ATPMB; Mitochondrial ATP Synthetase, Beta Subunit;
Function
Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F1. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Biological Process
Angiogenesis Source: UniProtKB
ATP biosynthetic process Source: UniProtKB
Cellular response to interleukin-7 Source: Ensembl
Cristae formation Source: Reactome
Generation of precursor metabolites and energy Source: UniProtKB
Lipid metabolic process Source: Ensembl
Mitochondrial ATP synthesis coupled proton transport Source: UniProtKB
Mitochondrion organization Source: Reactome
Negative regulation of cell adhesion involved in substrate-bound cell migration Source: Ensembl
Osteoblast differentiation Source: UniProtKB
Positive regulation of blood vessel endothelial cell migration Source: CAFA
Proton transmembrane transport Source: UniProtKB
Regulation of intracellular pH Source: UniProtKB
Cellular Location
Mitochondrion inner membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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