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Mouse Anti-ATP6V1B1 Recombinant Antibody (1H6) (CBMAB-A4086-YC)

Provided herein is a Mouse monoclonal antibody against Human ATPase H+ Transporting V1 Subunit B1. The antibody can be used for immunoassay techniques, such as FC, IF, IHC-P, WB.
See all ATP6V1B1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
1H6
Antibody Isotype
IgG1
Application
FC, IF, IHC, WB

Basic Information

Immunogen
Full length human recombinant protein of human ATP6V1B1 produced in HEK293T cell.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:2,000
IF(ICC)1:100
IHC1:150
FC1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATPase H+ Transporting V1 Subunit B1
Introduction
ATP6V1B1 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, z
Entrez Gene ID
UniProt ID
Alternative Names
ATPase H+ Transporting V1 Subunit B1; ATPase, H+ Transporting, Lysosomal 56/58kDa, V1 Subunit B1; Endomembrane Proton Pump 58 KDa Subunit; Vacuolar Proton Pump Subunit B 1; Vacuolar Proton Pump 3; V-ATPase Subunit B 1; ATP6B1; VPP3; VATB;
Function
Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:16769747).
V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091).
Essential for the proper assembly and activity of V-ATPase (PubMed:16769747).
In renal intercalated cells, mediates secretion of protons (H+) into the urine thereby ensuring correct urinary acidification (PubMed:16769747).
Required for optimal olfactory function by mediating the acidification of the nasal olfactory epithelium (By similarity).
Biological Process
Adult behavior Source: Ensembl
ATP metabolic process Source: Ensembl
Calcium ion homeostasis Source: UniProtKB
Cellular response to amino acid starvation Source: Reactome
Chloride ion homeostasis Source: Ensembl
Excretion Source: UniProtKB
Inner ear morphogenesis Source: UniProtKB
Insulin receptor signaling pathway Source: Reactome
Ion transmembrane transport Source: Reactome
Olfactory behavior Source: Ensembl
Ossification Source: HGNC-UCL
Phagosome acidification Source: Reactome
pH reduction Source: UniProtKB
Potassium ion homeostasis Source: Ensembl
Prostaglandin metabolic process Source: Ensembl
Proton transmembrane transport Source: HGNC-UCL
Regulation of gene expression Source: Ensembl
Regulation of macroautophagy Source: ParkinsonsUK-UCL
Regulation of pH Source: HGNC-UCL
Renal sodium excretion Source: Ensembl
Renal sodium ion transport Source: Ensembl
Renal water homeostasis Source: Ensembl
Sensory perception of sound Source: UniProtKB
Transferrin transport Source: Reactome
Cellular Location
Apical cell membrane; Basolateral cell membrane
Involvement in disease
Renal tubular acidosis, distal, with progressive nerve deafness (dRTA-D): An autosomal recessive disease characterized by the association of renal distal tubular acidosis with sensorineural hearing loss. Distal renal tubular acidosis is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis. It is due to functional failure of alpha-intercalated cells of the cortical collecting duct of the distal nephron, where vectorial proton transport is required for urinary acidification.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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