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Mouse Anti-BAIAP2 Recombinant Antibody (3F3-2D3) (CBMAB-A0703-LY)

The product is antibody recognizes BAIAP2. The antibody 3F3-2D3 immunoassay techniques such as: WB, ELISA.
See all BAIAP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F3-2D3
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
BAIAP2 (AAH32559, 1 a.a. ~ 512 a.a) full-length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
BAI1 Associated Protein 2
Introduction
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms
Entrez Gene ID
10458
UniProt ID
Q9UQB8
Alternative Names
BAP2; IRSP53
Function
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
Biological Process
Actin crosslink formation Source: UniProtKB
Actin filament bundle assembly Source: UniProtKB
Axonogenesis Source: ProtInc
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
Insulin receptor signaling pathway Source: ProtInc
Plasma membrane organization Source: InterPro
Positive regulation of actin cytoskeleton reorganization Source: GO_Central
Positive regulation of actin filament polymerization Source: GO_Central
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of cell shape Source: UniProtKB
Response to bacterium Source: UniProtKB
Vascular endothelial growth factor receptor signaling pathway Source: Reactome
Cellular Location
Cytoskeleton; Cytoplasm; Membrane; Filopodium; Ruffle. Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
PTM
Phosphorylated on tyrosine residues by INSR in response to insulin treatment.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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