BAIAP2

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Full Name

BAI1 Associated Protein 2

Function

Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.

Biological Process

Actin crosslink formation Source: UniProtKB
Actin filament bundle assembly Source: UniProtKB
Axonogenesis Source: ProtInc
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
Insulin receptor signaling pathway Source: ProtInc
Plasma membrane organization Source: InterPro
Positive regulation of actin cytoskeleton reorganization Source: GO_Central
Positive regulation of actin filament polymerization Source: GO_Central
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of cell shape Source: UniProtKB
Response to bacterium Source: UniProtKB
Vascular endothelial growth factor receptor signaling pathway Source: Reactome

Cellular Location

Cytoskeleton; Cytoplasm; Membrane; Filopodium; Ruffle. Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.

PTM

Phosphorylated on tyrosine residues by INSR in response to insulin treatment.