Mouse Anti-BAIAP2 Recombinant Antibody (CBYY-0172) (CBMAB-0173-YY)

Name: Mouse Anti-BAIAP2 Recombinant Antibody (CBYY-0172)
SKU: CBMAB-0173-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-0172

Application

WB, ELISA

Immunogen

Recombinant Protein.

Specificity

Human, Mouse

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.09% sodium azide

Concentration

0.5 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

BAI1 Associated Protein 2

Introduction

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforMouse.[provided by RefSeq, Jan 2009]

Entrez Gene ID

10458

UniProt ID

Q9UQB8

Alternative Names

BAI1 Associated Protein 2; Insulin Receptor Substrate Protein Of 53 KDa; Insulin Receptor Substrate Of 53 KDa; Insulin Receptor Substrate P53/P58; Fas Ligand-Associated Factor 3; BAI1-Associated Protein 2; IRSp53/58; IRSP53;

Function

Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.

Biological Process

Actin crosslink formation Source: UniProtKB
Actin filament bundle assembly Source: UniProtKB
Axonogenesis Source: ProtInc
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
Insulin receptor signaling pathway Source: ProtInc
Plasma membrane organization Source: InterPro
Positive regulation of actin cytoskeleton reorganization Source: GO_Central
Positive regulation of actin filament polymerization Source: GO_Central
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of cell shape Source: UniProtKB
Response to bacterium Source: UniProtKB
Vascular endothelial growth factor receptor signaling pathway Source: Reactome

Cellular Location

Cytoskeleton; Cytoplasm; Membrane; Filopodium; Ruffle. Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.

PTM

Phosphorylated on tyrosine residues by INSR in response to insulin treatment.

Clark, S. L., Chan, R. F., Zhao, M., Xie, L. Y., Penninx, B. W., Aberg, K. A., & van den Oord, E. J. (2020). Dual methylation and hydroxymethylation study in blood and brain identifies BAIAP2 as a mediator of gene expression differences associated with alcohol use disorder. medRxiv.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

BAIAP2 Matched Antibody Pair (126) (CAT#: APMAB-126LY)

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Mouse Anti-BAIAP2 Recombinant Antibody (CBYY-0171) (CAT#: CBMAB-0172-YY)

Mouse Anti-BAIAP2 Recombinant Antibody (CBYY-0170) (CAT#: CBMAB-0171-YY)

BAIAP2 Matched Antibody Pair (126) (CAT#: APMAB-126LY)

Mouse Anti-BAIAP2 Recombinant Antibody (CBYY-0169) (CAT#: CBMAB-0170-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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