Mouse Anti-BAIAP2L1 Recombinant Antibody (CBYY-0175) (CBMAB-0176-YY)

Name: Mouse Anti-BAIAP2L1 Recombinant Antibody (CBYY-0175)
SKU: CBMAB-0176-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYY-0175

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 213-357 mapping within an internal region of BAIAP2L1 of human origin.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

BAI1 Associated Protein 2 Like 1

Introduction

This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]

Entrez Gene ID

55971

UniProt ID

Q9UHR4

Alternative Names

BAI1 Associated Protein 2 Like 1; Insulin Receptor Tyrosine Kinase Substrate; BAI1-Associated Protein 2-Like Protein 1; IRTKS; Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2-Like Protein 1; BAI1-Associated Protein 2-Like 1;

Function

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.

Biological Process

Actin crosslink formation Source: GO_Central
Actin filament bundle assembly Source: GO_Central
Plasma membrane organization Source: InterPro
Positive regulation of actin cytoskeleton reorganization Source: UniProtKB
Positive regulation of actin filament polymerization Source: UniProtKB
Regulation of insulin receptor signaling pathway Source: InterPro
Response to bacterium Source: UniProtKB

Cellular Location

Cytoskeleton. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.

PTM

Phosphorylated on tyrosine in response to insulin.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-BAIAP2L1 Recombinant Antibody (CBYY-1975) (CAT#: CBMAB-2324-YY)

Mouse Anti-BAIAP2L1 Recombinant Antibody (2A4) (CAT#: CBMAB-A0704-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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