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Mouse Anti-BAIAP2L1 Recombinant Antibody (CBYY-0176) (CBMAB-0177-YY)

This product is mouse antibody that recognizes BAIAP2L1. The antibody CBYY-0176 can be used for immunoassay techniques such as: ICC, WB
See all BAIAP2L1 antibodies
Published Data
Mouse Anti-BAIAP2L1 Recombinant Antibody (CBYY-0176) in Immunoblot
Mouse bone marrow-derived macrophages cultured in the presence of M-CSF (10 ng/ml) with or without RANKL (10 ng/ml) for the indicated times were subjected to immunoblot analysis with antibodies against IRTKS, NFATc1 or γ-tubulin (loading control). ...View More
Oikawa, T., & Matsuo, K. (2012). Possible role of IRTKS in Tks5-driven osteoclast fusion. Communicative & Integrative Biology, 5(5), 511-515.

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-0176
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen
Recombinant BAIAP2L1 of human origin.
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
IHC-P1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BAI1 Associated Protein 2 Like 1
Introduction
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]
Entrez Gene ID
55971
UniProt ID
Q9UHR4
Alternative Names
BAI1 Associated Protein 2 Like 1; Insulin Receptor Tyrosine Kinase Substrate; BAI1-Associated Protein 2-Like Protein 1; IRTKS; Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2-Like Protein 1; BAI1-Associated Protein 2-Like 1;
Function
May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.
Biological Process
Actin crosslink formation Source: GO_Central
Actin filament bundle assembly Source: GO_Central
Plasma membrane organization Source: InterPro
Positive regulation of actin cytoskeleton reorganization Source: UniProtKB
Positive regulation of actin filament polymerization Source: UniProtKB
Regulation of insulin receptor signaling pathway Source: InterPro
Response to bacterium Source: UniProtKB
Cellular Location
Cytoskeleton. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
PTM
Phosphorylated on tyrosine in response to insulin.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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